Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially) present with predominant or isolated psychiatric symptoms. These cases can be difficult to classify, and diagnostic approaches… Read more »
Archiv nach Monat:: September 2026
Neuronal translational control in physiology, infection and inflammation.
Neurons are highly specialized cells whose function depends on dynamic regulation of gene expression. With increasing subcellular compartmentalization, neuronal gene expression becomes less dependent on transcription in the perinuclear region and tends to be increasingly controlled by local translation. The integrated stress response is a central, evolutionarily conserved pathway of translational regulation that maintains neuronal… Read more »
The effects of smoking and vaping on multiple sclerosis onset and disease progression: An umbrella review.
Background: Tobacco smoking has been implicated in multiple sclerosis (MS) onset and progression. However, findings are dispersed across reviews with differing quality and scope. Objectives: This umbrella review synthesised systematic reviews to provide a comprehensive overview of evidence, knowledge gaps, and inform future research about the effects of exposure to combustible tobacco and the use… Read more »
Neurons as cytokine sensors in the central nervous system.
Cytokines are key messenger molecules that bridge the nervous and immune systems through a bidirectional signalling network. Beyond their roles in development and homeostasis, neuronal cytokine sensing allows the central nervous system (CNS) to detect early immune perturbations, such as those triggered by emerging infections. Because neurons are postmitotic cells, rapid antipathogen responses are essential… Read more »
Real-life walking speed: A new marker of progression in a primary progressive multiple sclerosis cohort study?
Background: Primary progressive multiple sclerosis (PPMS) involves gradual disability accumulation driven by neurodegeneration. Standard outcomes, including the Expanded Disability Status Scale (EDSS) and timed 25-foot walk (T25FW), lack sensitivity to subtle functional changes. Real-life walking speed (RWS) measured with wearable sensors may offer a more responsive marker of progression. Objectives: In a prospective cohort (2012-2022)… Read more »
Intracellular complement factor H protects neurons during CNS inflammation
Neurodegeneration is a major driver of disability in multiple sclerosis (MS), the most common chronic inflammatory disease of the central nervous system (CNS)1. Retinal ganglion cells (RGCs), a heterogeneous neuronal population in the eye, undergo degeneration in MS and provide a model to study neuronal subtype-specific resilience to inflammatory injury2. However, the neuron-intrinsic mechanisms underlying… Read more »
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