Background: People with multiple sclerosis (pwMS) often experience impaired quality of life (QoL) despite receiving standard care. Digital therapeutics (DTx) may offer support, but prior trials yielded mixed results, possibly due to active controls and high baseline QoL. Objectives: We evaluated a DTx (levidex) as an adjunct to treatment as usual (TAU) in pwMS with… Read more »
Archiv nach Monat:: August 2026
„Perspectives of participating neurologists and study nurses – Mixed-methods process evaluation of a web-based program for relapse management in multiple sclerosis (POWER@M2)“
Background: Relapsing-remitting multiple sclerosis is a chronic inflammatory disease of the central nervous system and the leading cause of disability in young adults. In Germany, 90% of relapses are treated with high-dose intravenous glucocorticoids, despite limited evidence for long-term benefit and international preference for oral administration. Time constraints often hinder informed decision-making. The multicentre Randomized… Read more »
Impact of tobacco and alcohol consumption on disease progression and MRI in people with multiple sclerosis: results of the prospective cohort study NationMS.
Background: Lifestyle factors, such as smoking cigarettes and alcohol consumption, can influence disease progression in Multiple Sclerosis (MS). Objective: This study aimed to investigate the associations of smoking cigarettes and alcohol consumption with clinical parameters in people with MS (pwMS). Design: This is a prospective cohort study, analysing data from the German NationMS cohort. Methods:… Read more »
“ Preventing the next stroke: nurse-led decision and adherence coaching to empower people with stroke (StrokeCompass) versus usual care – study protocol for a stepped-wedge pilot trial. „
„Introduction: Recurrent stroke prevention is important for people who have suffered a stroke or transient ischaemic attack (TIA), as they are at increased risk of having another stroke. Nevertheless, treatment adherence is often low. Therefore, the StrokeCompass project was initiated to enhance medication adherence by empowering individuals who have had a stroke to take an… Read more »
Real-world practices and challenges of radiologically isolated syndrome: results of a cross-sector survey by the DACH MS guidelines group.
Objective: To evaluate real-world Radiologically isolated syndrome (RIS) management practices across Germany, Austria, and Switzerland and identify key gaps for future guideline development. Methods: Between October 1 and October 16, 2024, neurologists across university hospitals, teaching hospitals, municipal clinics, and private practices in Germany, Austria, and Switzerland (DACH) participated in an anonymous online survey on… Read more »
The transcriptional cortical response to daily torpor in Phodopus sungorus.
Torpor is an essential evolutionary strategy that allows mammals to conserve resources under extreme environmental conditions. Although the hypothalamus is a key regulator of systemic acclimatisation to energy scarcity and reduced temperature, it remains unclear how the cortex, with its high metabolic demand, endures this state. Here, we performed RNA sequencing on neuronal and non-neuronal… Read more »
“ Two cases of probable Neuro-Behçet syndrome treated with autologous HSCT. „
Neuro-Behçet syndrome (NBS) is a rare but detrimental neurological manifestation of the Behçet syndrome (BS) – a chronic multisystemic inflammatory disease. NBS is frequently associated with brainstem and spinal cord lesions, often resulting in substantial neurological disability. Atypical clinical presentations can pose significant challenges for diagnosis and treatment of NBS. Here, we report the clinical… Read more »
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