Background: Neuroaxonal and synaptic loss are hallmarks of multiple sclerosis (MS), the most common autoimmune disorder of the central nervous system. However, it remains unclear at which disease stages synaptic pathology occurs. We hypothesised that synaptic proteins in plasma and cerebrospinal fluid (CSF) reflect synaptic injury in MS. Methods: To identify synaptic proteins lost during… Read more »
Archiv nach Monat:: Mai 2026
Autologous haematopoietic stem cell transplantation in multiple sclerosis: outcomes and predictors from German real-world data.
Background: Autologous haematopoietic stem cell transplantation (aHSCT) represents a treatment option for highly aggressive multiple sclerosis (MS). Here, we report outcome analyses from the two largest German centres performing aHSCT in MS.Methods: In this retrospective analysis, people with (pw) MS who underwent aHSCT between 2007 and 2025 were included. Outcomes comprise no evidence of disease… Read more »
Socioeconomic impact of depression and pain in patients with neuromyelitis optica spectrum disorders.
Background: Neuromyelitis optica spectrum disorders (NMOSD) are associated with a high burden of depression, pain, and physical disability, all of which significantly impair quality of life. At the same time, discussions on the cost-effectiveness of treatment strategies are gaining importance. However, it is not yet known whether specific symptom burdens are particularly cost-driving. This study… Read more »
Preventive strategies in neuroimmunology
“ Neuroimmunological diseases arise from a complex interplay of genetic susceptibility, environmental exposures, and immune-mediated mechanisms. In this context, modifiable lifestyle and environmental factors may contribute to disease risk and disease course, at least in a subset of patients. Accordingly, while disease-modifying immunotherapy remains the cornerstone of treatment, lifestyle-related factors are increasingly recognized as relevant… Read more »
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