Key Publications

Rothammer N, Woo MS, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K, Wagner I, Haferkamp U, Pless O, Merkler D, Engler JB, Friese MA.

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis.

Sci Adv. 2022 Aug 5;8(31)

Brasanac J, Ramien C, Gamradt S, Tänzer A, Glau L, Ritter K, Patas K, Agorastos A, Wiedemann K, Demiraley C, Fischer F, Otte C, Weygandt M, Gold SM.

Immune signature of multiple sclerosis-associated depression.

Brain Behav Immun. 2021 Dec 1;S0889-1591(21)00625-5.

Kaufmann M, Evans H, Schaupp AL, Engler JB, Kaur G, Willing A, Kursawe N, Schubert C, Attfield KE, Fugger L, Friese MA.

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis

Med (N Y). 2021 Mar 12;2(3):296-312

Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Nornig S, Bauer S, Wagner I,Egervari K, Raber J, Duvoisin RM, Pless O, Merkler D, Friese MA.

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.

J Exp Med. 2021 May 3;218(5).e20201290

Gold SM, Köhler-Forsberg O, Moss-Morris R, Mehnert A, Miranda JJ, Bullinger M, Steptoe A, Whooley MA, Otte C

Comorbid depression in medical diseases

Nat Rev Dis Primers. 2020 Aug 20;6(1):69

Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber N, Willing A, Rosenkranz SC, Diemert A, Harrison A, Vignali M, Sanders C, Robins HS, Tolosa E, Heesen C, Arck PC, Scheffold A, Chan K, Emerson RO, Friese MA, Gold SM.

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis.

Cell Rep. 2019 Oct 22;29(4):810-815

Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA.

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis.

Nat Neurosci. 2019 Jun;22(6):887-896

Pöttgen J, Moss-Morris R, Wendebourg J, Feddersen L, Lau S, Köpke S, Meyer B, Friede T, Penner I, Heesen C, Gold SM

Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):970-976

Stürner KH, Stellmann JP, Dörr J, Paul F, Friede T, Schammler S, Reinhardt S, Gellissen S, Weissflog G, Faizy TD, Werz O, Fleischer S, Vaas LAI, Herrmann F, Pless O, Martin R, Heesen C

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial).

J Neurol Neurosurg Psychiatry. 2018 Apr.;89(4):330-338

Heesen C, Haase R, Melzig S, Poettgen J, Berghoff M, Friedemann P, Zettl U, Marziniak M, Angstwurm K, Kern R, Ziemssen T, Stellmann JP

Perceptions on the value of bodily functions in multiple sclerosis.

Acta Neurol Scand. 2018 Mar;137(3):356-362

Ufer F, Vargas P, Engler JB, Tintelnot J, Schattling B, Winkler H, Bauer S, Kursawe N, Willing A, Keminer O, Ohana O, Salinas-Riester G, Pless O, Kuhl D, Friese MA.

Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation

Sci. Immunol. 2016 Sep 23;1(3):eaaf86665

Gold SM, Enck P, Hasselmann H, Friede T, Hegerl U, Mohr DC, Otte C

Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework.

Lancet Psychiatry. 2017 Sep;4(9):725-732

Engler JB, Kursawe N, Solane ME, Patas K, Wehrmann S, Heckmann N, Lühder F, Reichart HM, Arck PC, Gold SM, Friese MA

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E181-E190.

Fischer A, Schröder J, Vettorazzi E, Wolf OT, Pöttgen J, Lau S, Heesen C, Moritz S, Gold SM.

An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial.

Lancet Psychiatry 2015;2:217-23.

Briken S, Gold SM, Patra S, Vettorazzi E, Harbs D, Tallner A, Ketels G, Schulz KH, Heesen C.

Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial.

Mult. Scler. 2014;20:382-90.

Köpke S, Kern S, Ziemssen T, Berghoff M, Kleiter I, Marziniak M, Paul F, Vettorazzi E, Pöttgen J, Fischer K, Kasper J, Heesen C.

Evidence-based patient information programme in early multiple sclerosis: a randomised controlled trial.

J. Neurol. Neurosurg. Psychiatr. 2014;85:411-8.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA.

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

Nat Med. 2012 Dec;18(12):1805-11

Friese MA, Jakobsen KB, Friis L, Etzensperger R, Craner MJ, McMahon RM, Jensen LT, Huygelen V, Jones EY, Bell JI, Fugger L.

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

Nat Med. 2008 Nov;14(11):1227-35

Köpke S, Kasper J, Mühlhauser I, Nübling M, Heesen C.

Patient education program to enhance decision autonomy in multiple sclerosis relapse management: a randomized-controlled trial.

Mult. Scler. 2009;15:96-104.

Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, Fugger L.

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system.

Nat Med. 2007 Dec;13(12):1483-9

Original Articles

Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Woo MS, Friese MA, Lohr C, Grochowska KM.

Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling.

Glia. 2024 Apr 17.

Holz A, Obi N, Ahrens W, Berger K, Bohn B, Brenner H, Fischer B, Fricke J, Führer A, Gastell S, Greiser KH, Harth V, Heise JK, Holleczek B, Keil T, Klett-Tammen CJ, Leitzmann M, Lieb W, Meinke-Franze C, Michels KB, Mikolajczyk R, Nimptsch K, Peters A, Pischon T, Riedel O, Schikowski T, Schipf S, Schmidt B, Schulze MB, Stang A, Hellwig K, Riemann-Lorenz K, Heesen C, Becher H.

Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO).

BMC Neurol. 2024 Apr 13;24(1):123

Schubert C, Schiffmann I, Farschtschi SC, Emile JF, Friese MA.

Treatment of Cerebral Histiocytosis With Low Dose of Cobimetinib: A Report of 2 Cases.

Neurol Neuroimmunol Neuroinflamm. 2024 May;11(3):e200233

Fischbach F, Richter J, Pfeffer LK, Fehse B, Berger SC, Reinhardt S, Kuhle J, Badbaran A, Rathje K, Gagelmann N, Borie D, Seibel J, Ayuk F, Friese MA, Heesen C, Kröger N.

CD19-targeted chimeric antigen receptor T cell therapy in two patients with multiple sclerosis.

Med. 2024 Mar 22:S2666-6340

Wenzel L, Haker M, Heesen C, Kasper J, Köpke S, Rahn AC.

Evaluating Relapse Knowledge in People with Multiple Sclerosis: A Cross-Sectional Study on the Development and Validation of the Relapse Knowledge Questionnaire.

Mult Scler Relat Disord. 2024 Jan 12;83:105381

Therriault J, Woo MS, Salvadó G, Gobom J, Karikari TK, Janelidze S, Servaes S, Rahmouni N, Tissot C, Ashton NJ, Benedet AL, Montoliu-Gaya L, Macedo AC, Lussier FZ, Stevenson J, Vitali P, Friese MA, Massarweh G, Soucy JP, Pascoal TA, Stomrud E, Palmqvist S, Mattsson-Carlgren N, Gauthier S, Zetterberg H, Hansson O, Blennow K, Rosa-Neto P.

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology.

Mol Neurodegener. 2024 Jan 7;19(1):2

Braun B, Fischbach F, Richter J, Pfeffer LK, Fay H, Reinhardt S, Friese MA, Stellmann JP, Kröger NM, Heesen C, Häußler V.

Benefits of aHSCT over alemtuzumab in patients with multiple sclerosis besides disability and relapses: Sustained improvement in cognition and quality of life.

Mult Scler Relat Disord. 2023 Dec 27.

Duchow A, Bellmann-Strobl J, Friede T, Aktas O, Angstwurm K, Ayzenberg I, Berthele A, Dawin E, Engels D, Fischer K, Flaskamp M, Giglhuber K, Grothe M, Havla J, Hümmert MW, Jarius S, Kaste M, Kern P, Kleiter I, Klotz L, Korporal-Kuhnke M, Kraemer M, Krumbholz M, Kümpfel T, Lohmann L, Ringelstein M, Rommer P, Schindler P, Schubert C, Schwake C, Senel M, Bergh FT, Tkachenko D, Tumami H, Trebst C, Vardakas I, Walter A, Warnke C, Weber MS, Wickel J, Wildemann B, Winkelmann A, Paul F, Stellmann JP, Häußler V; Neuromyelitis Optica Study Group (NEMOS).

Time to disability milestones and annualized relapse rates in NMOSD and MOGAD.

Ann Neurol. 2024 Apr;95(4):720-732

Wendlandt M, Kürten AJ, Beiersdorfer A, Schubert Ch, Samad K, Sauer J, Pinto MC, Schulz K, Friese MA, Gee CE, Hirnet D, Lohr C.

A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis.

Front Immunol. 2023 Nov 23:14:1273837

Meyer-Arndt L, Brasanac J, Gamradt S, Bellmann-Strobl J, Maurer L, Mai K, Steward T, Spranger J, Schmitz-Hübsch T, Paul F, Gold SM, Weygandt M.

Body mass,neuro-hormonal stress processing, and disease activity in lean to obese people with multiple sclerosis.

J Neurol. 2023 Nov 27

Woo MS, Nilsson J, Therriault J, Rahmouni N, Brinkmalm A, Benedet AL, Ashton NJ, Macedo AC, Servaes S, Wang YT, Tissot C, Fernandez Arias J, Hosseini SA, Chamoun M, Lussier FZ, Karikari TK, Stevenson J, Mayer C, Ferrari-Souza JP, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P.

14-3-3 ζ/δ-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2.

Neuroinflammation. 2023 Nov 24;20(1):278

Winkler I, Engler JB, Vieira V, Bauer S, Liu YH, Di Liberto G, Grochowska KM, Wagner I, Bier J, Bal LC, Rothammer N, Meurs N, Egervari K, Schattling B, Salinas G, Kreutz MR, Huang YS, Pless O, Merkler D, Friese MA.

MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration.

Sci Adv. 2023 Nov 24;9(47):eadi6855

Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE.

Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease.

Nat. Commun. 2023 Nov 15;14(1):7372

Woo MS, Tissot C, Lantero-Rodriguez J, Snellman A, Therriault J, Rahmouni N, Macedo AC, Servaes S, Wang YT, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Benedet AL, Ashton NJ, Karikari TK, Triana-Baltzer G, Kolb HC, Stevenson J, Mayer C, Kobayashi E, Massarweh G, Friese MA, Pascoal TA, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P.

Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive individuals.

Alzheimers Dement. 2024 Feb;20(2):1166-1174.

Eisenhut K, Faber J, Engels D, Gerhards R, Lewerenz J, Doppler K, Sommer C, Markewitz R, Falk Kim K, Rössling R, Pruess H, Finke C, Wickel J, Geis C, Ratusnzny D, Pfeffer LK, Bittner S, Piepgras J, Kraft A, Klausewitz J, Nuscher B, Kümpfel T, Thaler FS; German Network for Research on Autoimmune Encephalitis (GENERATE).

Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies.

Neurol Neuroimmunol Neuroinflamm 2023 Nov 1;11(1):e200176

Dalgas U, Riemenschneider M, Gold SM, Kalron A, Beckerman H, de Groot V, Dennett R, Edwards T, Pilutti LA, Freeman J.

The MoXFo initiative – study design: Considerations related to study design and methodology in exercise research for people with multiple sclerosis.

Mult Scler 2023 Oct 26

Rosenkranz SC, Ploughman M, Hvid LG, Zimmer P, Erickson K, Stellmann JP, Centonze D, Friese MA.

The MoxFo initiative-Mechanisms of action: Biomarkers in multiple sclerosis exercise studies.

Mult Scler 2023 Nov;29(13):1569-1577

Motl RW, Casey B, Learmonth YC, Latimer-Cheung A, Kinnett-Hopkins DL, Marck CH, Carl J, Pfeifer K, Riemann-Lorenz K, Heesen C, Coote S.

The MoXFo initiative – adherence: Exercise adherence, compliance and sustainability among people with multiple sclerosis: An overview and roadmap for research.

Mult Scler 2023 Oct 26

Kutzinski M, Krause N, Riemann-Lorenz K, Meyer B, Heesen C

Acceptability of digital health application to empower persons with multiple sclerosis with moderate to severe disability: single-arm prospective pilot study.

BMC Neurol. 2023 Oct 23;23(1):382

Daniel N, Bruns I, Casey B, Coote S, Daubmann A, Heesen C, Riemann-Lorenz K.

„Activity Matters was great – I now realize: if I move, I’m fitter.“: development and process evaluation of a web-based program for persons with multiple sclerosis.

Disabil Rehabil. 2023 Oct 20:1-10

Krause N, Derad C, von Glasenapp B, Riemann-Lorenz K, Temmes H, van de Loo M, Friede T, Asendorf T, Heesen C; POWER@MS1 study group.

Association of health behaviour and clinical manifestation in early multiple sclerosis in Germany – Baseline characteristics of the POWER@MS1 randomised controlled trial.

Mult Scler Relat Disord. 2023 Oct 5;79:105042

Chorschew A, Kesgin F, Bellmann-Strobl J, Flachenecker P, Schiffmann I, Rosenthal F, Althoff P, Drebinger D, Arsenova R, Rasche L, Dorsch EM, Heesen C, Paul F, Stellmann JP, Schmitz-Hübsch T.

Translation and validation of the multiple sclerosis walking scale 12 for the German population – the MSWS-12/D.

Health Qual Life Outcomes. 2023 Oct 9;21(1):110

Goldin K, Riemann-Lorenz K, Daubmann A ,Pöttgen J, Krause N, Schröder H, Heesen C.

Health behaviors of people with multiple sclerosis and its associations with MS related outcomes: a German clinical cohort.

Front Neurol. 2023 Sep 13:14:1172419

Bayas A, Berthele A, Blank N, Dreger P, Faissner S, Friese MA, Gerdes LA, Grauer OM, Häussler V, Heesen C, Janson D, Korporal-Kuhnke M, Kowarik M, Kröger N, Lünemann JD, Martin R, Meier U, Meuth S, Muraro P, Platten M, Schirmer L, Stürner KH, Stellmann JP, Scheid C, Bergh FT, Warnke C, Wildemann B, Ziemssen T.

Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline.

Ther Adv Neurol Disord. 2023 Sep 28;16:17562864231180730

Gold SM, Friede T, Meyer B, Moss-Morris R, Hudson J, Asseyer S, Bellmann-Strobl J, Leisdon A, Ißels L, Ritter K, Schymainski D, Pomeroy H, Lynch SG, Cozart JS, Thelen J, Román CAF, Cadden M, Guty E, Lau S, Pöttgen J, Ramien C, Seddiq-Zai S, Kloidt AM, Wieditz J, Penner IK, Paul F, Sicotte NL, Bruce JM, Arnett PA, Heesen C.

Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial.

Lancet Digit Health. 2023 Oct;5(10):e668-e678

Brehm TT, Heyer A, Woo MS, Fischer M, von der Meirschen M, Wichmann D, Jarczak D, Roedl K, Schmiedel S, Addo MM, Lütgehetmann M, Christner M, Huber S, Lohse AW, Kluge S, Schulzer Zur Wiesch J.

Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 – A retrospective single-center cohort study.

J Infect Public Health. 2023 Nov;16(11):1806-1812

Woo MS, Ufer F, Sonner JK, Belkacemi A, Tintelnot J, Sáez PJ, Krieg PF, Mayer C, Binkle-Ladisch L, Engler JB, Bauer S, Kursawe N, Vieira V, Mannebach S, Freichel M, Flockerzi V, Vargas P, Friese MA.

Calcium Channel ß3 subunit regulates ATP-dependent migration of dendritic cells.

Sci Adv. 2023 Sep;9(38):eadh1653.

Salmen A, Hoepner R, Fleischer V, Heldt M, Gisevius B, Motte J, Ruprecht K, Schneider R, Fisse AL, Grüter T, Lukas C, Berthele A, Giglhuber K, Flaskamp M, Mühlau M, Kirschke J, Bittner S, Groppa S, Lüssi F, Bayas A, Meuth S, Heesen C, Trebst C, Wildemann B, Then Bergh F, Antony G, Kümpfel T, Paul F, Nischwitz S, Tumani H, Zettl U, Hemmer B, Wiendl H, Zipp F, Gold R.

Factors associated with depressive mood at the onset of multiple sclerosis – an analysis of 781 patients of the German NationMS cohort.

Ther Adv Neurol Disord. 2023 Sep 8;16

Köhler-Forsberg O, Stiglbauer V, Brasanac J, Chae WR, Wagener F, Zimbalski K, Jefsen OH, Liu S, Seals MR, Gamradt S, Correll CU, Gold SM, Otte C.

Efficacy and Safety of Antidepressants in Patients With Comorbid Depression and Medical Disease: An Umbrella Systematic Review and Meta-Analysis.

JAMA Psychiatry. 2023 Dec 1;80(12):1196-1207.

Renner A, Bätge SJ, Filser M, Lau S, Pöttgen J, Penner IK.

Non-pharmacological randomized intervention trial for the management of neuropsychological symptoms in outpatients with progressive multiple sclerosis

Appl Neuropsychol Adult. 2023 Aug 31;1-13

Woo MS, Shafiq M, Fitzek A, Dottermusch M, Altmeppen H, Mohammadi B, Mayer C, Bal LC, Raich L, Matschke J, Krasemann S, Pfefferle S, Brehm TT, Lütgehetmann M, Schädler J, Addo MM, Schulze Zur Wiesch J, Ondruschka B, Friese MA, Glatzel M.

Vagus nerve inflammation contributes to dysautonomia in COVID-19.

Acta Neuropathol. 2023 Sep;146(3):387-394.

Rosenkranz SC, Gutmann L, Has Silemek AC, Dorr M, Häußler V, Lüpke M, Mönch A, Reinhardt S, Kuhle J, Tilsley P, Heesen C, Friese MA, Brandt A, Paul F, Zimmermann H, Stellmann JP.

Visual function resits early neurodegeneration in the visual system in primary progressive multiple sclerosis.

J Neurol Neurosurg Psychiatry. 2023 Nov;94(11):924-933

Heesen C., Solaria A.

Editorial: Shared decision-making in neurology.

Front Neurol. 2023 Jun 6;14:1222433

Tilsley P, Strohmeyer IA, Heinrich I, Rosenthal F, Patra S, Schulz KH, Rosenkranz SC, Ramien C, Pöttgen J, Heesen C, Has AC, Gold SM, Stellmann JP.

Physical fitness moderates the association between brain network impairment and both motor function and cognition in progressive multiple sclerosis.

J Neurol. 2023 JOct;270(10):4876-4888.

Peper J, Köpke S, Solari A, Giordano A, Gold SM, Hellwig K, Steinberg L, Steckelberg A, Heesen C, Rahn AC.

Knowledge and worries on motherhood choice in multiple sclerosis – a cross-sectional study on patient-reported outcome measures.

Mult Scler Relat Disord. 2023 Aug;76:104789

Mayer Ch, Woo MS,Brehm TT, Heyer A, Fischer M, Fischbach F, Bal LC, Addo MM, Kluge S,Thomalla G, Schweingruber N, Schulze zur Wiesch J.

History of cerebrovascular disease but not dementia increases the risk for secondary vascular events during SARS-CoV-2 infection with presumed Omicron variant: a retrospective observational study.

Eur J Neurol. 2023 Aug;30(8):2297-2304

Woo MS, Mayer C, Fischer M, Kluge S, Roedl 2, Gerloff C, Czorlich P, Thomalla G, Schulze zur Wiesch J, Schweingruber N.

Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit.

Neurol Res Pract. 2023 May 4;5(1):17

Thaler C, Sedlacik J, Forkert ND, Stellmann JP, Schön G, Fiehler J, Gellißen S.

Effect of geometric distortion correction on thickness and volume measurements of cortical parcellations in 3D T1w gradient echo sequences.

PLoS One. 2023 Apr 14;18(4):e0284440

Woo MS, Mayer C, Brehm TT, Andersen G, Weigel A, Löwe B, Lohse AW, Addo MM, Gerloff C, Knobloch JKM, Schulze zur Wiesch J, Friese MA.

Absence of self-reported neuropsychiatric and somatic symptoms after Omicron variant SARS-CoV-2 breakthrough infections.

Brain Commun. 2023 Mar 25;5(2):fcad092

Gold SM, Landray MJ, Medhurst N, Otte C.

Fast tracking informative clinical trials: lessons for mental health.

Lancet Psychiatry. 2023 Jun;10(6):376-378

Chae WR, Baumert J, Nübel J, Brasanac J, Gold SM, Hapke U, Otte C.

Associations between individual depressive symptoms and immunometabolic characteristics in major depression.

Eur Neuropsychopharmacol. 2023 Mar 24;71:25-40

Heesen C, Rahn AC.

The challenge of pregnancy in women with multiple sclerosis.

Lancet Neurol. 2023 Apr;22(4):288-289.

Ufer F, Ziegler SM, Altfeld M, Friese MA.

Case report: JAK inhibition as promising treatment option of fatal RVCLS due to TREX1 mutation (pVAL235Glyfs*6).

Front Neurol. 2023 Feb 21;14:11118369

Baetge SJ, Filser M, Renner A, Raithel LM, Lau S, Pöttgen J, Penner IK.

Supporting brain health in multiple sclerosis: exploring the potential of neuroeducation combined with practical mindfulness exercises in the management of neuropsychological symptoms

Neurol Neurosurg Psychiatry. 2023 Sep;94(9):718-725.

Abu Heijleh AP, Huck K, Jähne K, Tan CL, Lanz TV, Epping L, Sonner JK, Meuth SG, Henneberg A, Opitz CA, Herold-Mende C, Sahm F, Platten M, Sahm K.

Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System.

Int J Tryptophan Res. 2023 Feb 9:16:11786469231153111

Hümmert MW, Stern C, Paul F, Duchow A, Bellmann-Strobl J, Ayzenberg I, Schwake C, Kleiter I, Hellwig K, Jarius S, Wildemann B, Senel M, Berthele A, Giglhuber K, Luessi F, Grothe M, Klotz L, Schülke R, Gingele S, Faiss JH, Walter A, Warnke C, Then Bergh F, Aktas O, Ringelstein M, Stellmann JP, Häußler V, Havla J, Pellkofer H, Kümpfel T, Kopp B, Trebst C.

Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study).

Mult Scler. 2023 Jun;29(7):819-831

Krieg PF, Sonner JK, Kurelic R, Engler JB, Scharenberg MF, Bauer S, Nikolaev VO, Friese MA.

GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses.

Front Immunol. 2023 Jan 24;13:1113348.

Hannah Kapell, Luca Fazio, Julia Dyckow, Sophia Schwarz, Andrés Cruz-Herranz, Christina Mayer, Joaquin Campos, Elisa D Este, Wiebke Möbius, Christian Cordano, Anne-Katrin Pröbstel, Marjan Gharagozloo, Amel Zulji, Venu Narayanan Naik, Anna-Katharina Delank, Manuela Cerina, Thomas Müntefering, Celia Lerma-Martin, Jana K Sonner, Jung H Sin, Paul Disse, Nicole Rychlik, Khalida Sabeur, Manideep Chavali, Rajneesh Srivastava, Matthias Heidenreich, Kathryn C Fitzgerald, Guiscard Seebohm, Christine Stadelmann, Bernhard Hemmer, Michael Platten, Thomas J Jentsch, Maren Engelhardt, Thomas Budde, Klaus-Armin Nave, Peter A Calabresi, Manuel A Friese, Ari J Green, Claudio Acuna, David H Rowitch , Sven G Meuth, Lucas Schirmer.

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.

J Clin Invest. 2023 Apr 3;133(7):e164223

Martin W Hümmert, Franziska Bütow, Daria Tkachenko, Ilya Ayzenberg, Thivya Pakeerathan, Kerstin Hellwig, Luisa Klotz, Vivien Häußler, Jan-Patrick Stellmann, Clemens Warnke, Yasemin Goereci, Thorleif Etgen, Felix Luessi, Paul Bronzlik, Stefan Gingele, Ann-Sophie Lauenstein, Ingo Kleiter, Paulus S Rommer, Friedemann Paul, Judith Bellmann-Strobl, Ankelien Duchow, Florian Then Bergh, Refik Pul, Annette Walter, Hannah Pellkofer, Tania Kümpfel, Mosche Pompsch, Markus Kraemer, Philipp Albrecht, Orhan Aktas, Marius Ringelstein, Makbule Senel, Katrin Giglhuber, Achim Berthele, Sven Jarius, Brigitte Wildemann, Corinna Trebst; Neuromyelitis Optica Study Group (NEMOS)

Effects of the COVID-19 Pandemic on Patients with NMO Spectrum Disorders and MOG-Antibody-Associated Diseases: COPANMO(G)-Study.

Neurol Neuroimmunol Neuroinflamm. 2023 Jan 24;10(2):e200082

Jordan-Paiz A, Martrus G, Steinert FL, Kaufmann M, Sagebiel AF, Schreurs RRCE, Rechtien A, Baumdick ME, Jung JM, Möller KJ, Wegner L, Grüttner C, Richtert L, Thünauer R, Schroeder-Schwarz J, von Goudoever JB, Geijtenbeek TBH, Altfeld M, Pals ST, Perez D, Klarenbeek PL, Tomuschat C, Sauter G, Königs I, Schumacher U, Friese MA, Melling N, Reinshagen K, Bunders MJ.

CXCR5+PD-1++ CD4+ T cells colonize infant intestines early in life and promote B cell maturation

Cell Mol Immunol. 2023 Feb;20(2):201-213

Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski M, Goldschmidt J, Friese MA, Rossner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR.

Jacob-induced transcriptional inactivation of CREB promotes Aß-induced synapse loss in Alzheimer’s disease.

EMBO J. 2023 Feb 15;42(4):e112453

Heesen C, Rahn AC, Köpke S.

Communication with people with MS: A key role for evidence-based patient information.

Patient Educ. Couns. 2022 DE;105(12):3339-3340

Woo MS, Brehm TT, Fischer M, Heyer A, Wichmann D, Jordan S, Nörz D, Lütgehetmann M, Addo MM, Lohse AW, Schmiedel S, Kluge S, Schulze zur Wiesch J.

Sotrovimab in Hospitalized Patients with SARS-CoV-2 Omicron Variant Infection: a Propensity Score-Matched Retrospective Cohort Study.

Microbiol Spectr. 2023 Feb 14;11(1):e0410322

Lutfullin I, Eveslage M , Bittner S, Antony G , Flaskamp M, Luessi F , Salmen A, Gisevius B , Klotz L , Korsukewitz C ,  Berthele A ,  Groppa S , Then Bergh F , Wildemann B , Bayas A, Tumani H ,  Meuth SG , Trebst C , Zettl UK,  Paul F ,Heesen C, Kuempfel T, Gold R , Hemmer B, Zipp F, Wiendl H , Lünemann JD , German Competence Network Multiple Sclerosis (KKNMS)

Association of obesity with disease outcome in multiple sclerosis.

J Neurol Neruosurg Psychiatry. 2023 Jan;94(1):57-61

Has Silemek AC, Nolte G, Pöttgen J, Engel AK, Heesen C, Gold SM, Stellmann JP

Topological reorganization of brain network might contribute to the resilience of cognitive functioning in mildly disabled relapsing remitting multiple sclerosis.

J Neurosci Res. 2023 Jan;101(1):143-161

Wenzel L, Heesen C, Peper J, Grentzenberg K, Faßhauer E, Scheiderbauer J, Thale F, Meyer B, Köpke S, Rahn AC.

An interacitive web-based programme on relapse management for people with multiple sclerosis (POWER@MS2) – development, feasibility, and pilot testing of a complex intervention.

Front Neurol. 2022 Sep 23;13:914814

Dannemann M, Milaneschi Y, Yermakovich D, Stiglbauer V, Kariis HM, Krebs K, Friese MA, Otte C; Estonian Biobank Research Team, Lehto K, Penninx BWJH, Kelso J, Gold SM.

Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes.

Transl Psychiatry. 2022 Oct5;12(1):433

Fründt O, Fadhel M, Heesen C, Seddiq Zai S, Gerloff C, Vettorazzi E, Pöttgen J, Buhmann C.

Do Impulse Control Disorders Impair Car Driving Performance in Patients with Parkinson’s Disease?

J Parkinsons Dis. 2022;12(7):2261-2275

Krause N, Riemann-Lorenz K, Rahn AC, Pöttgen J, Köpke S, Meyer B, Thale F, Temmes H, van de Loo M, Gold SM, Heesen C.

„That would have been the perfect thing after diagnosis“: development of a digital lifestyle management application in multiple sclerosis.

Ther Adv Neurol Disord. 2022 Sep 6;15:17562864221118729

Sippel A, Riemann-Lorenz K, Pöttgen J, Wiedemann R, Drixler K, Bitzer EM, Holmberg C, Lezius S, Heesen C.

Validation of the German eHealth impact questionnaire for online health information users affected by multiple sclerosis.

BMC Med Inform Decis Mak. 2022 Aug 16;22(1):219

Roig MB, Krotka P, Burman CF, Glimm E, Gold SM, Hees K, Jacko P, Koeig F, Magirr D, Mesenbrink P, Viele K, Posch M.

On model-based time trend adjustments in platform trials with non-concurrent controls.

BMC Med Res Methodol. 2022 Aug 15;22(1):228

Rothammer N, Woo MS, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K, Wagner I, Haferkamp U, Pless O, Merkler D, Engler JB, Friese MA.

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis.

Sci Adv. 2022 Aug 5;8(31)

Beckmann H, Heesen C, Augustin M, Blome C.

The 27-Item Multiple Sclerosis Quality of Life Questionnaire: A New Brief Measure Including Treatment Burden and Work Life.

Int J MS Care. 2022 Jul-Aug;24(4):147-153

Wisgalla A, Ramien C, Streitz M, Schlickeiser S, Lupu AR, Diemert A, Tolosa E, Arck PC, Bellmann-Strobl J, Siebert N, Heesen C, Paul F, Friese MA, Infante-Duarte C, Gold SM.

Alterations of NK Cell Phenotype During Pregnancy in Multiple Sclerosis.

Front Immunol. 2022 Jul 4;13:907994.

Schubert C, Schulz K, Träger S, Plath AL, Omriouate A, Rosenkranz SC, Morellini F, Friese MA, Hirnet D.

Neuronal Adenosine A1 Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation.

Front Cell Neurosci. 2022 Jun 30;16:912030

Basso L, Boecking B, Neff P, Brueggemann P, El-Ahmad L, Brasanac J, Rose M, Gold SM, Mazurek B

Negative Associations of Stress and Anxiety Levels with Cytotoxic and Regulatory Natural Killer Cell Frequency in Chronic Tinnitus.

Front Psychol. 2022 Jun 23;13:871822

Kaufmann M, Schaupp AL, Sun R, Coscia F, Dendrou CA, Cortes A, Kaur G, Evans HG, Mollbrink A, Navarro JF, Sonner JK, Mayer C, DeLuca GC, Lundeberg J, Matthews PM, Attfield KE, Friese MA, Fugger L.

Identification of early neurodegenerative pathways in progressive multiple sclerosis.

Nat Neurosci. 2022 Jul;25(7):944-955

Ghaidar D, Sippel A, Riemann-Lorenz K, Kofahl C, Morrison R, Kleiter I, Schmidt S, Dettmers C, Schulz H, Heesen C.

Experiences of persons with multiple sclerosis with rehabilitation: A qualitative study interview.

BMC Health Serv Res. 2022 Jun 11;22(1):770

Elkalhii-Wilhelm S, Sippel A, Riemann-Lorenz K, Kofahl C, Scheiderbauer J, Arnade S, Kleiter I, Schmidt S, Heesen C.

Experiences of persons with Multiple Sclerosis with lifestyle adjustment: A qualitative interview study.

PLoS One. 2022 May 27;17(5):e0268988.

Steinberg L, Peper J, Köpke S, Solari A, Giordano A, Gold SM, Hellwig K, Heesen C, Rahn AC.

Motherhood choice in multiple sclerosis (MoMS) development and piloting of patient-reported outcome measures.

Mult Scler Relat Disord. 2022 Jul;63:103831

Ri Chae W, Nübel J, Baumert J, Gold SM, Otte C.

Association of depression and obesity with C-reactive protein in Germany: a large nationally representative study.

Brain Behav Immun. 2022 Jul;103:223-231

Heesen C, Mokry C, Salmen A, Hegen H, Mäurer M, Warnke C, Gehring K, Berthele A, Meier U.

German guideline for diagnosis and treatment of multiple sclerosis – a survey focusing neurologists in daily practise.

Mult Scler Relat Disord. 2022 Apr 25;63:103828

Sippel A, Scheiderbauer J, Eklund D, Arnade S, Schmidt S, Kleiter I, Morrison R, Kofahl C, Heesen C.

Development and evaluation of a website with patients experiences of multiple sclerosis: a mixed methods study.

BMC Neurol. 2022 Apr 20;22(1):146

Brasanac J, Hetzer S, Asseyer S, Kuchling J, Bellmann-Strobl J, Ritter K, Gamradt S, Scheel M, Haynes JD, Brandt AU, Paul F, Gold SM, Weygandt M.

Central stress processing, T-cell responsitivity to stress hormones and disease severity in multiple sclerosis.

Brain Commun. 2022 Apr 4;4(2)

Freund M, Schiffmann I, Rahn AC, Chard D, Lukas C, Scheiderbauer J, Sippel A, Heesen C.

Understanding Magnetic Resonance Imaging in Multiple Sclerosis (UMIMS): Development and Piloting of an Online Education Program About Magnetic Resonance Imaging for People With Multiple Sclerosis.

Front Neurol. 2022 Mar 28;13:856240

Fearey BC, Binkle L, Mensching D, Schulze C, Lohr C, Friese MA, Oertner TG, Gee CE.

A glibenclamide-sensitive TRPM4-mediated component von CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis.

Sci Rep. 2022 Apr 9;12(1)

Röhling HM, Althoff P, Arsenova R, Drebinger D, Gigengack N, Chorschew A, Kroneberg D, Rönnefarth M, Ellermeyer T, Rosenkranz SC, Heesen C, Behnia B, Hirano S, Kuwabara S, Paul F, Brandt AU, Schmitz-Hübsch T.

Proposal for Post Hoc Quality Control in Instrumented Motion Analysis Using Markerless Motion Capture: Development and Usability Study.

JMIR Hum Factors. 2022 Apr 1;9(2)

Dietmaier JM, von dem Knesebeck O, Heesen C, Kofahl C

Personality and its association with self-management in multiple sclerosis.

Mult Scler Relat Disord. 2022 May;61:103752

Ambra MG, Pöttgen J, Anglada E, Menendez R, Hoyer J, Giordano A, Pakenham KI, Galan I, Solari A.

Cross-Country Adaptation of a Psychological Flexibility Measure: The Comprehensive Assessment of Acceptance and Commitment Therapy Processes.

Int J Environ Res Public Health. 2022 Mar 8;19(6):3150

Heesen C, Rosenkranz SC.

Physical exercise in multiple sclerosis is not just a symptomatic therapy, it has a disease-modifying effect: No.

Mult Scler. 2022 May;28(6):861-862

Schneider A, Fasshauer E, Scheiderbauer J, Warnke C, Köpke S, Kasper J, Toussaint M, Temmes H, Hemmer B, Schiffmann I, Rahn AB, Heesen C.

Development and evaluation of evidence-based patient information handbooks about multiple sclerosis immunotherapies.

Mult Scler Relat Disord. 2022 Apr;60:103728.

GENERATE

Clinical, serological and genetic predictors of response to immunotherapy in anti-IgLON5 disease.

Brain. 2023 Feb 13;146(2):600-611

Artmann A, Rahn AC, Köpke S, Thomalla G, Heesen C, Alegiani AC.

Risk communication in acute stroke patients – from qualitative data to a pilot randomised controlled trial.

Z Evid Fortbild Qual Gesundhwes. 2022 Apr;169:19-27

Pöttgen J, Friede T, Lau S, Gold SM, Letsch C, Bender G, Flachenecker P, Heesen C, Penner IK.

Managing neuropsychological impairment in multiple sclerosis – Controlled study on a standardized metacognitive intervention (MaTiMS)

Mult Scler Relat Disord. 2022 Mar;59:103687.

Brasanac J, Gamradt S, Otte C, Milaneschi Y, Monzel AS, Picard M, Gold SM.

Cellular specificity of mitochondrial and immunometabolic features in major depression.

Mol Psychiatry. 2022 May;27(5):2370-2371

Testud B, Delacour C, El Ahmadi AA, Brun G, Girard N, Duhamel G, Heesen C, Häußler V, Thaler C, Has Silemek AC, Stellmann JP

Brain grey matter perfusion in primary progressive multiple sclerosis: Mild decrease over years and regional associations with cognition and hand function.

Eur J Neurol. 2022 Jun;29(6):1741-1752.

Hümmert MW, Schöppe LM, Bellmann-Strobl J, Siebert N, Paul F, Duchow A, Pellkofer H, Kümpfel T, Havla J, Jarius S, Wildemann B, Berthele A, Bergh FT, Pawlitzki M, Klotz L, Kleiter I, Stangel M, Gingele S, Weber MS, Faiss JH, Pul R, Walter A, Zettl U, Senel M, Stellmann JP, Häußler V, Hellwig K, Ayzenberg I, Aktas O, Ringelstein M, Schreiber-Katz O, Trebst C; Neuromyelitis Optica Study Group (NEMOS).

Costs and Health-Related Quality of Life in Patients with NMO Spectrum Disorders and MOG-Antibody-Associated Disease: CHANGE NOM Study.

Neurology. 2022 Mar 15;98(11):e1184-e1196

Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, König EM, Bodem J, Franzenburg S, Franke A,Moese S, Müller FJ,Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O.

The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.

Stem Cell Reports. 2022 Jan 3;S2213-6711(21)00650-0.

Rosenkranz SC, Häußler V, Kolster M, Willing A, Matschke J, Röcken C, Stürner K, Leypoldt F, Tolosa E, Friese MA.

Treating sarcoidosis-associated progressive multifocal leukoencephalopathy with infliximab.

Brain Commun. 2021 Dec 16;4(1)

Fleischer V, Ciolac D, Gonzalez-Escamilla G, Grothe M, Strauss S, Molina Galindo LS, Radetz A, Salmen A, Lukas C, Klotz L, Meuth SG, Bayas A, Paul F, Hartung HP, Heesen C, Stangel M, Wildemann B, Bergh FT, Tackenberg B, Kümpfel T, Zettl UK, Knop M, Tumani H, Wiendl H, Gold R, Bittner S, Zipp F, Groppa S, Muthuraman M; German Competence Network Multiple Sclerosis (KKNMS).

Subcortical volumes as early predictors of fatigue in multiple sclerosis.

Ann Neurol. 2021 Dec 30

Thaler C, Hartramph I, Stellmann JP, Heesen C, Bester M, Fiehler J, Gellißen S

T1 Relaxation Times in the Cortex and Thalamus Are Associated With Working Memory and Information Processing Speed in Patients with Multiple Sclerosis

Front Neurol. 2021 Dec 3;12:789812

Mayer-Arndt L, Schmitz-Hübsch T, Bellmann-Strobl J, Brandt A, Haynes J, Gold SM, Paul F, Weygandt M.

Neural Processes of Psychological Stress and Relaxation Predict the Future Evolution of Quality of Life in Multiple Sclerosis

Front Neurol 2021 Nov 23;12:753107.

Brasanac J, Ramien C, Gamradt S, Tänzer A, Glau L, Ritter K, Patas K, Agorastos A, Wiedemann K, Demiraley C, Fischer F, Otte C, Weygandt M, Gold SM.

Immune signature of multiple sclerosis-associated depression.

Brain Behav Immun. 2021 Dec 1;S0889-1591(21)00625-5.

Lagrèze W, Küchlin S, Ihorst G, Grotejohann B, Beisse F, Volkmann M, Heinrich S, Abrecht P, Ungewiss J, Wörner M, Hug M, Wolf S, Diem R, Tone study group (Stellmann, Heesen, Rosenkranz).

Safety and efficacy of erythropoietin for the treatment of patients with optic neuritis (TONE): a randomised, double-blind, multicentre, placebo-controlled study

Front Neurol 2021 Nov 23;12:753107.

Ringelstein M, Ayzenberg L, Lindenblatt G, Fischer K, Gahlen A, Novi G, Hayward-Könnecke H, Schippling S, Rommer P, Kornek B, Zrzavy T, Biotti D, Crion J, Audoin B, Berthele A, Giglhuber K, Zephir H, Kümpfel T, Berger R, Röther J, Häußler V, Stellmann J, Whittam D, Jacob A, Kraemer M, Gueguen A, Deschamps R, Bayas A, Hümmert M, Trebst C, Haarmann A, Jarius S, Wildemann, Grothe M, Siebert N, Ruprecht K, Paul F, Collongues N, Marignier R, Levy M, Karenfort M, Deppe M, Albrecht P, Hellwig K, Gold R, Hartung H, Meuth S, Kleiter I, Aktas O.

Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG-Associated Disease and Neuromyelitis Optica Spectrum Disorders

Neurol Neuroimmunol Neuroinflamm 2021 Nov 16;9(1):e1100.

Gamradt S, Hasselmann H, Taenzer A, Brasanac J, Stiglbauer V, Sattler A, Sajitz-Hermstein M, Kierszniowska S, Ramien C, Nowacki J, Mascarell-Maricic L, Wingenfeld K, Piber D, Ströhle A, Kotsch J, Paul F, Otte C, Gold SM.

Reduced mitochondrial respiration in T cells of patients with major depressive disorder

iScience 2021 Oct 16;24(11):103312.

Dürr M, Nissen G, Sühs K, Schwenkenbecher P, Geis C, Ringelstein N, Hartung H, Friese MA, Kaufmann M, Malter M, Madlener M, Thaler F, Kümpfel T, Senel M, Häusler M, Schneider H, Bergh F, Kellinghaus C, Zettl U, Wandinger K, Melzer N, Gross C, Lange P, Dreyhaupt, Tumani H, Leypoldt F, Lewerenz J.

CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis

Neurol Neuroimmunol Neuroinflammn 2021 Oct 25;8(6):e1086.

Sippel A, Riemann-Lorenz K, Scheiderbauer J, Kleiter I, Morrison R, Kofahl C, Heesen C.

Patients experiences with multiple sclerosis disease-modifying therapies in daily life – a qualitative interview study

BMC Health Serv Res 2021 Oct 22;21(1):1141.

Kurelic R, F.Krieg P, Sonner J, Bhaiyan G, Ramos G, Frantz S, Friese MA, Nikolaev V.

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

Front Pharmacol 2021 Oct 5;12:748798.

Huang Y, Peng K, Popejoy A, Hu J, Nowicki T, Gold SM, Quintana-Murci L, Fuentes-Guajardo M, Shugay M, Greiff V, Burkhardt A, Alachkar H, Mangul S.

Ancestral diversity is limited in published T cell receptor sequencing studies

Immunity 2021 Oct 12;54(10):2177-2179.

Wenzel L, Heesen C, Scheiderbauer J, van de Loo M, Köpke S, Rahn Ac.

Evaluation of an interactive web-based programme on relapse management for people with multiple sclerosis (POWER@MS2): study protocol for a process evaluation accompanying a randomised controlled trial

BMJ Open 2021 Oct 1;11(10):e046874.

Heestermans M, Naudin C, Mailer R, Konrath S, Klaetschke, Jämsä A, Frye M, Deppermann C, Paula G, Kuta P, Friese M, Gelderblom M, Sickmann A, Preston R, Nofer J, Rose-Jahn S, Butler L, Salomon O, Stavrou E, Renné T.

Identification of the factor XII contact activation site enables sensitive coagulation diagnostics

Nat Commun 2021 Sep 22;12(1):5596.

Giovannelli J, Ciron J, Cohen M, Kim H, Kim S, Stellmann J, Kleiter I, McCreay M, Greenberg B, Deschamps R, Audoin B, Maillart E, Papeix C, Collongues N, Bourre B, Laplaud D, Ayrignac X, Durand-Dubief F, Ruet A, Vukusic S, Marignier R, Dauchet L, Zephir H.

A meta-analysis comparing first-line immunosuppressants in neuromyelitis optica

Ann Clin Transl Neurol 2021 Oct;8(10):2025-2037

Schwenkenbecher P, Skripuletz T, Lange P, Dürr M, Konen FF, Möhn N, Ringelstein M, Menge T, Friese MA, Melzer N, Malter MP, Häusler M, Thaler FS, Stangel M, Lewerenz J, Sühs KW.

Intrathecal Antibody Production Against Epstein-Barr, Herpes Simplex, and Other Neurotropic Viruses in Autoimmune Encephalitis

Neurol Neuroimmunol Neuroinflamm 2021 Aug 24;8(6):e1062.

Haker M, Heesen C, Wenzel L, Köpke S, Rahn AC, Jasper J.

Decision-making about corticosteroids in relapses of multiple sclerosis – development of a questionnaire based on the theory of planned behaviour

Mult Scler Relat Disord. 2021 Oct;55:103182.

Heinrich l, Rosenthal F, Patra S, Schulz KH, Welsch GH, Vettorazzi E, Rosenkranz SC, Stellmann JP, Ramien C, Pöttgen J, Gold SM, Heesen C.

Arm Ergometry to Improve Mobility in Progressive Multiple Sclerosis (AMBOS)-Results of a Pilot Randomized Controlled Trial

Front Neurol. 2021 Jul 19;12:644533.

Melief J, Huitinga I, Gold SM.

The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects.

Handb Clin Neurol. 2021;181:119-126

Woo MS, Haag F, Nierhaus A, Jarczak D, Roedl K, Mayer C, Brehm TT, van der Meirschen M, Hennigs A, Christopeit M, Fiedler W, Karagiannis P, Burdelski C, Schultze A, Huber S, Addo MM, Schmiedel S, Friese MA, Kluge S, Schulze Zur Wiesch J

Multi-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19

iScience. 2021 Jul 23;24(7):102752

Ramaglia V, Dubey M, Malpede MA, Petersen N, de Vries SI, Ahmed SM, Lee DSW, Schenk GJ, Gold SM, Huitinga I, Gommerman JL, Geurts JJG, Kole MHP

Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory

Acta Neuropathol. 2021 Oct;142(4):643-667.

Ayzenberg I, Richter D, Henke E, Asseyer S, Paul F, Trebst C, Hümmert MW, Havla J, Kümpfel T, Ringelstein M, Aktas O, Wildemann B, Jarius S, Häußler V, Stellmann JP, Senel M, Klotz L, Pellkofer HL, Weber MS, Pawlitzki M, Rommer PS, Berthele A, Wernecke KD, Hellwig K, Gold R, Kleiter I, NEMOS (Neuromyelitis Optica Study Group)

Pain, Depression, and Quality of Life in Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study of 166 AQP4 Antibody-Seropositive Patients

Neurol Neuroimmunol Neuroinflamm. 2021 Apr 20;8(3):e985

Zhang HW, Huck K, Jähne K, Cichon F, Sonner JK, Ufer F, Bauer S, Woo MS, Green E, Lu K, Kilian M, Friese MA, Platten M, Sahm K.

Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma

Oncoimmunology. 2021 May 14;10(1):1920739

Kneussel M, Friese MA

SnapShot: Neuronal dysfunction in inflammation

Neuron. 2021 May 19;109(10):1754-1754

Häußler V, Ufer F, Pöttgen J, Wolschke C, Friese MA, Kröger N, Heesen C, Stellmann JP

aHSCT is superior to alemtuzumab in maintaining NEDA and improving cognition in multiple sclerosis

Ann Clin Transl Neurol 2021 Jun;8(6):1269-1278

Pust GEA, Randerath J, Goetzmann L, Weierstall R, Korzinski M, Gold SM, Dettmers C, Ruettner B, Schmidt R.

Association of Fatigue Severity With Maladaptive Coping in Multiple Sclerosis: A Data-Driven Psychodynamic Perspective

Front Neurol. 2021 Apr 7;12:652177.

Zangemeister WH, Heesen C, Röhr D, Gold SM.

Oculomotor Fatigue and Neuropsychological Assessments mirror Multiple Sclerosis Fatigue

J Eye Mov Res. 2020 Sep 13;13(4):10.16910

Has Silemek AC, Ranjeva JP, Bertrand Audoin, Heesen C, Gold SM, Kühn S, Weygandt M, Stellmann JP.

Delayed access to conscious processing in multiple sclerosis: Reduced cortical activation and impaired structural connectivity

Hum Brain Mapp. 2021 Apr 7.

Poch T, Krause J, Casar C, Liwinski T, Glau L, Kaufmann M, Ahrenstorf AE, Hess LU, Ziegler AE, Martrus G, Lunemann S, Sebode M, Li J, Schwinge D, Krebs CF, Franke A, Friese MA, Oldhafer KJ, Fischer L, Altfeld M, Lohse AW, Huber S, Tolosa E, Gagliani N, Schramm C.

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis

J Hepatol. 2021 Aug;75(2):414-423

Bellmann-Strobl J, Paul F, Wuerfel J, Dörr J, Infante-Duarte C, Heidrich E, Körtgen B, Brandt A, Pfüller C, Radbruch H, Rust R, Siffrin V, Aktas O, Heesen C, Faiss J, Hoffmann F, Lorenz M, Zimmermann B, Groppa S, Wernecke KD, Zipp F.

Epigallocatechin Gallate in Relapsing-Remitting Multiple Sclerosis: A Randomized, Placebo-Controlled Trial

Neurol Neuroimmunol Neuroinflamm. 2021 Mar 24;8(3):e981

Kaufmann M, Evans H, Schaupp AL, Engler JB, Kaur G, Willing A, Kursawe N, Schubert C, Attfield KE, Fugger L, Friese MA.

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis

Med (N Y). 2021 Mar 12;2(3):296-312

Stellmann JP, Wanke N, Maarouf A, Gellißen S, Heesen C, Audoin B, Gold SM, Zaaraoui W, Poettgen J.

Cognitive performance shows domain specific associations with regional cortical thickness in multiple sclerosis

Neuroimage Clin. 2021 Feb 24; 30:102606

Blome C, Carlton J, Heesen C, Janssen MF, Lloyd A, Otten M, Brazier J.

How to measure fluctuating impairments in people with MS: development of an ambulatory assessment version of the EQ-5D-5L in an exploratory study.

Qual Life Res. 2021 Jul;30(7):2081-2096

Rosenkranz SC, Kaulen B, Zimmermann HG, Bittner AK, Dorr M, Stellmann JP

Validation of Computer-Adaptive Contrast Sensitivity as a Tool to Assess Visual Impairment in Multiple Sclerosis Patients

Front Neurosci. 2021 Feb 23;15:591302

Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Nornig S, Bauer S, Wagner I,Egervari K, Raber J, Duvoisin RM, Pless O, Merkler D, Friese MA.

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.

J Exp Med. 2021 May 3;218(5).e20201290

Graf LM, Rosenkranz SC, Hölzemer A, Hagel C, Goebell E, Jordan S, Friese MA, Addo MM, Schulze Zur Wiesch J, Beisel C.

Clinical Presentation and Disease Course of 37 Consecutive Cases of Progressive Multifocal Leukoencephalopathy (PML) at a German Tertiary-Care Hospital: A Retrospective Observational Study.

Front Neurol. 2021 Feb 4;12:632535.

Krause N, Riemann-Lorenz K, Steffen T, Rahn AC, Pöttgen J, Stellmann JP, Köpke S, Friede T, Icks A, Vomhof M, Temmes H, van de Loo M, Gold SM, Heesen C.

Study protocol for a randomised controlled trial of a web-based behavioural lifestyle programme for emPOWERment in early Mulitiple Sclerosis (POWER@MS1).

BMJ Open. 2021 Feb 16;11(2):e041720

Rahn AC, Wenzel L, Icks A, Stahmann A, Scheiderbauer J, Grentzenberg K, Vomhof M, Montalbo J, Friede T, Heesen C, Köpke S.

Development and evaluation of an interactive web-based decision-making programme on relapse management for people with multiple sclerosis (POWER@MS2)-study protocol for a randomised controlled trial.

Trials. 2021 Feb 14;22(1):139.

Rosenkranz SC, Shaposhnykov AA, Träger S, Engler JB, Witte ME, Roth V, Vieira V, Paauw N, Bauer S, Schwencke-Westphal C, Schubert C, Bal LC, Schattling B, Pless O, van Horssen J, Freichel M, Friese MA

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

Elife.2021 Feb 10;10:e61798.

Thaler C, Kyselyova AA, Faizy TD, Nawka MT, Jespersen S, Hansen B, Stellmann JP, Heesen C, Stürner KH, Stark M, Fiehler J, Bester M, Gellißen S

Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging

PLoS One 2021 Feb 4;16(2):e0245844.

Silveira SL, Riemann-Lorenz K, Heesen C, Motl RW.

Current and Long-Term Physical Activity Among Adults with Multiple Sclerosis in the United States: COM-B Variables as Explanatory Factors

Int J Behav Med. 2021 Oct;28(5):561-574

Barabasch A, Riemann-Lorenz K, Kofahl C, Scheiderbauer J, Eklund D, Kleiter I, Kasper J, Köpke S, Lezius S, Zapf A, Rahn AC, Heesen C.

Impact of a multimedia website with patient experiences of multiple sclerosis (PExMS) on immunotherapy decision making: study protocol for a pilot randomised controlled trial in a mixed-methods design.

Pilot Feasibility Stud. 2021 Jan 7;7(1):16.

Stiglbauer V, Gamradt S, Scherzer M, Brasanac J, Otte C, Rose M, Hofmann T, Hinkelmann K, Gold SM

Immunological substrates of depressive symptoms in patients with severe obesity: An exploratory study

Cell Biochem Funct. 2021 Apr;39(3):423-431

Heine J, Prüß H, Scheel M, Brandt AU, Gold SM, Bartsch T, Paul F, Finke C.

Transdiagnostic hippocampal damage patterns in neuroimmunological disorders

Neuroimage Clin. 2020;28:102515

Woo MS, Malsy J, Pöttgen J, Seddiq Zai S, Ufer F, Hadjilaou A, Schmiedel S, Addo MM, Gerloff C, Heesen C, Schulze Zur Wiesch J, Friese MA

Frequent neurocognitive deficits after recovery from mild COVID-19

Brain Commun. 2020 Nov 23;2(2)

Patrick Ostkamp, Anke Salmen, Béatrice Pignolet, Dennis Görlich, Till F M Andlauer, Andreas Schulte-Mecklenbeck , Gabriel Gonzalez-Escamilla, Florence Bucciarelli, Isabelle Gennero, Johanna Breuer, Gisela Antony, Tilman Schneider-Hohendorf, Nadine Mykicki, Antonios Bayas, Florian Then Bergh, Stefan Bittner, Hans-Peter Hartung, Manuel A Friese, Ralf A Linker, Felix Luessi, Klaus Lehmann-Horn, Mark Mühlau, Friedemann Paul, Martin Stangel, Björn Tackenberg, Hayrettin Tumani, Clemens Warnke, Frank Weber, Brigitte Wildemann, Uwe K Zettl, Ulf Ziemann, Bertram Müller-Myhsok, Tania Kümpfel, Luisa Klotz, Sven G Meuth, Frauke Zipp, Bernhard Hemmer, Reinhard Hohlfeld, David Brassat, Ralf Gold, Catharina C Gross , Carsten Lukas , Sergiu Groppa , Karin Loser , Heinz Wiendl , Nicholas Schwab , German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network

Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

Proc Natl Acad Sci USA 2021 Jan 5;118(1):e2018457118

Anna C Alegiani, Anne C Rahn, Anke Steckelberg, Götz Thomalla, Christoph Heesen, Sascha Köpke

Quality of Stroke Patient Information Applied in Randomized Controlled Trials-Literature Review

Front. Neurol. 2020 Dec 7;11:526515.

Meyer-Arndt L, Hetzer S. Asseyer S, Bellmann-Strobl J, Scheel M, Stellmann JP, Heesen C, Engel AK, Brandt AU, Haynes JD, Paul F, Gold SM, Weygandt M.

Blunted neural and psychological stress processing predicts future grey matter atrophy in multiple sclerosis.

Neurobiol Stress. 2020 Jul 27;13:100244

Er-Lukowiak M, Duan Y, Rassendren F, Ulmann L, Nicke A, Ufer F, Friese MA, Koch-Nolte F, Magnus T, Rissiek B.

A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice

iScience. 2020 Nov 27;23(12)

Schiffmann I, Freund M, Vettorazzi E, Stellmann JP, Heyer-Borchelt S, D'Hooghe M, Häußler V, Rahn AC, Heesen C.

Assessing the effect of an evidence-based patient online educational tool for people with multiple sclerosis called UMIMS-understanding magnetic resonance imaging in multiple sclerosis: study protocol for a double-blind, randomized controlled trial

Trials. 2020 Dec 9;21(1):1008.

Benecke M, Kasper J, Heesen C, Schäffler N, Reissmann DR.

Patient autonomy in dentistry: demonstrating the role for shared decision making

BMC Med. Informations 2020 Dec 2;20(1):318.

Otte C, Chae WR, Nowacki J, Kaczmarczyk M, Piber D, Roepke S, Märschenz S, Lischewski S, Schmidt S, Ettrich B, Grabe HJ, Hegerl U, Hinkelmann K, Hofmann T, Janowitz D, Junghanns K, Kahl KG, Klein JP, Krueger THC, Leicht G, Prvulovic D, Reif A, Schoettle D, Strauss M, Westermair A, Friede T, Gold SM.

Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial

BMJ Open. 2020 Dec 1;10(12):e040119.

Pust GEA, Untiedt B, Randerath J, Barabasch A, Köpke S, Rahn AC, Hansen H, Heesen C.

Exploring Adherence to First-Line and Second-Line Immunotherapies in Multiple Sclerosis: An Interview Study

Int J MS Care. Sep-Oct 2020;22(5):219-225.

Montes-Cobos E, Huscher B, Engler JB, Woo MS, Binkle L, Bauer S, Kursawe N, Moles M, Friese MA, Ufer F.

Voltage-Gated Proton Channel Hv1 Controls TLR9 Activation in Plasmacytoid Dendritic Cells

J Immunol. 2020 Dec 1;205(11):3001-3010

Wakonig K, Eitel F, Ritter K, Hetzer S, Schmitz-Hübsch T, Bellmann-Strobl J, Haynes JD, Brandt AU, Gold SM, Paul F, Weygandt M.

Altered Coupling of Psychological Relaxation and Regional Volume of Brain Reward Areas in Multiple Sclerosis

Front Neurol. 2020 Oct 6;11:568850.

Kosch R, Schiffmann I, Daumer M, Lederer C, Scalfari A, Galea I, Scheiderbauer J, Rahn A, Heesen C.

Long-term prognostic counselling in people with multiple sclerosis using an online analytical processing tool.

Mult Scler. 2020 Oct 26

Rahn AC, Riemann-Lorenz K, Alegiani A, Pust GEA, van de Roemer A, Schmitz L, Vettorazzi E, Köpke S, Heesen C.

Comprehension of confidence intervals in audio-visual patient information materials for people with multiple sclerosis (COCO-MS): A web-based randomised controlled, parallel group trial

Patient Educ and Couns. 2021 May;104(5):1132-1139

Giovanetti AM, Barabasch A, Giordano A, Quintas R, Barello S, Graffigna G, Alifieri S, Schiffmann I, Muche-Borowski C, Borreani C, Heesen C, Solari A; ManTra project

Construction of a User-Led Resource for People Transitioning to Secondary Progressive Multiple Sclerosis: Results of an Internation Nominal Group Study

Front. Neurol. 2020 Aug 18;11:798

Pust GEA, Dettmers C, Randerath J, Rahn AC, Heesen C, Schmidt R, Gold SM

Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities

Front Psychiatry 2020 Aug 28;11:811.

Ringelstein M, Harmel J, Zimmermann H, Brandt AU, Paul F, Haarmann A, Buttmann M, Hümmert MW, Trebst C, Schroeder C, Ayzenberg I, Kleiter I, Hellwig K, Havla J, Kümpfel T, Jarius S, Wildemann B, Rommer P, Weber M, Pellkofer H, Röpke L, Geis C, Retzlaff N, Zettl U, Deppe M, Klotz L, Young K, Stellmann JP, Kaste M, Kermer P, Marouf W, Lauda F, Tumani H, Graf J, Klistorner S, Hartung HP, Aktas O, Albrecht P.

Author response: Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

Neurology. 2020 Sep 29;95(13):610.

Rosenkranz SC, Shaposhnykov A, Schnappauff O, Epping L, Vieira V, Heidermann K, Schattling B, Tsvilovskyy V, Liedtke W, Meuth SG, Freichel M, Gelderblom M, Friese MA

TRPV4-mediated regulation of the blood brain barrier is abolished during inflammation

Front Cell Dev Biol. 2020 Aug 27;8:849

Zhai Y, Nasseri N, Pöttgen J, Gezhelbash E, Heesen C, Stellmann JP.

Smartphone Accelerometry: A Smart and Reliable Measurement of Real-Life Physical Activity in Multiple Sclerosis and Healthy Individuals

Front Neruol. 2020 Aug 14;11:688

Voskuhl RR, Patel K, Paul F, Gold SM, Scheel M, Kuchling J, Cooper G, Asseyer S, Chien C, Brandt AU, Meyer CE, MacKenzie-Graham A.

Sex differences in brain atrophy in multiple sclerosis.

Biol Sex Differ. 2020 Aug 28;11(1):49

Gold SM, Köhler-Forsberg O, Moss-Morris R, Mehnert A, Miranda JJ, Bullinger M, Steptoe A, Whooley MA, Otte C

Comorbid depression in medical diseases

Nat Rev Dis Primers. 2020 Aug 20;6(1):69

Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE

Aerobic Exercise Induces Functional and Structural Reorganization of CNS Networks in Multiple Sclerosis: A Randomized Controlled Trial

Front Hum Neurosci. 2020 Jun 30;15:255

Marques RF, Engler JB, Küchler K, Jones RA, Lingner T, Salinas G, Gillingwater TH, Friese MA, Duncan KE

Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis mutants

Hum Mol Genet. 2020 Sep 29;29(16):2647-2661

Hermann J, Bender M, Schumacher D, Woo MS, Shaposhnykov A, Rosenkranz SC, Kuryshev V, Meier C, Guse AH, Friese MA, Freichel M, Tsvilovskyy V

Contribution of NAADP to Glutamate-Evoked Changes in CA2+ Homeostasis in Mouse Hippocampal Neurons

Front Cell Dev. Biol 2020 Jun 25;8:496

Gasperi C, Andlauer TFM, Keatin A, Knier B, Klein A, Pernpeintner V, Lichtner P, Gold R, Zipp F, Then Bergh F, Stangel M, Tumani H, Wildemann B, Wiendl H, Bayas A, Kümpfel T, Zettl UK, Linkner RA, Ziemann U, Knop M, Warnke C, Friese MA, Paul F, Tackenberg B, Berhele A, Hemmer B.

Genetic determinants of the humoral immune response in MS

Neurol Neuroimmunol Neuroinflamm. 2020 Jul 16;7(5)

Golde S, Heine J, Pöttgen J, Mantwill M, Lau S, Wingenfeld K, Otte C, Penner IK, Engel AK, Heesen C, Stellmann JP, Dziobek I, Finke C, Gold SM

Distinct Functional Connectivity Signartures of Impaired Social Cognition in Multiple Sclerosis

Front Neurol. 2020 Jun 25;11:507

Woo MS, Steins D, Häußler V, Kohsar M, Haag F, Elias-Hamp B, Heesen C, Lütgehetmann M, Schulze zur Wiesch J, Friese MA.

Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients.

J Neurol. 2021 Jan;268(1):5-7

Nasseri NN, Ghezelbash E, Zhai Y, Patra S, Riemann-Lorenz K, Heesen C, Rahn AC, Stellmann JP

Feasibility of a smartphone app to enhance physical activity in progressive MS: a pilot randomized controlled pilot trial over three months.

PeerJ. 2020 Jun 23;8:e9303

Witt G, Keminer O, Leu J, Tandon R, Meiser I, Willing A, Winschel I, Abt JC, Brändl B, Sébastien I, Friese MA, Müller FJ, Neubauer JC, Claussen C, Zimmermann H, Gribbon P, Pless O

An Automated and High-Throughput-Screening Compatible Pluripotent Stem Cell-Based Test Platform for Developmental and Reproductive Toxicity Assessment of Small Molecule Compounds

Cell Biol Toxicol. 2021 Apr;37(2):229-243.

Gunbey H, Has A, Aslan K, Saglam D, Avci U, Sayit A, Incesu L.

Microstructural white matter abnormalities in hypothyroidism evaluation with diffusion tensor imaging tract-based spatial statistical analysis

Radiol Med 2021 Feb;126(2):283-290.

Stürner KH, Werz O, Koeberle A, Otto M, Pless O, Leypoldt F, Paul F, Heesen C.

Lipid Mediator Profiles Predict Response to Therapy With an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis

Sci Rep. 2020 May 29;10(1):8776

Bittner S, Steffen F, Uphaus T, Muthuraman M, Fleischer V, Salmen A, Luessi F, Berthele A, Klotz L, Meuth SG, Bayas A, Paul F, Hartung HP, Linker R, Heesen C, Stangel M, Wildemann B, Then Bergh F, Tackenberg B, Kuempfel T, Weber F, Zettl UK, Ziemann U, Tumani H, Groppa S, Mühlau M, Hemmer B, Wiendl H, Gold R, Zipp F; KKNMS consortium

Clinical Implications of Serum Neurofilament in Newly Diagnosed MS Patients: A Longitudinal Multicentre Cohort Study

EBioMedicine. 2020 Jun;56:102807

Pust GEA, Untiedt B, Weierstall-Pust R, Randerath J, Barabasch A, Rahn AC, Heesen C.

Medication beliefs in first-line and second-line treated multiple sclerosis patients

Mult Scler Relat Disord. 2020 May 4;42:102144

Gharakhanlou R, Wesselmann L, Rademacher A, Lampit A, Negaresh R, Kaviani M, Oberste M, Motl RW, Sandroff BM, Bansi J, Baker JS, Heesen C, Zimmer P, Javelle F.

Exercise training and cognitive performance in persons with multiple sclerosis: A systematic review and multilevel meta-analysis of clinical trials.

Mult Scler. 2021 Nov;27(13):1977-1993.

Abrahamyan S, Eberspächer B, Hoshi MM, Aly L, Luessi F, Groppa S, Klotz L, Meuth SG, Schroeder C, Grüter T, Tackenberg B, Paul F, Then-Bergh F, Kümpfel T, Weber F, Stangel M, Bayas A, Wildemann B, Heesen C, Zettl U, Warnke C, Antony G, Hessler N, Wiendl H, Bittner S, Hemmer B, Gold R, Salmen A, Ruprecht K; German Competence Network Multiple Sclerosis (KKNMS); Other members of the KKNMS that acted as collaborators in this study.

Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis.

J Neurol Neurosurg Psychiatry. 2020 Jul;91(7):681-686

Faergeman SL, Evans H, Attfield KE, Desel C, Kuttikkatte SB, Sommerlund M, Jensen LT, Frokiaer J, Friese MA, Matthews PM, Luchtenborg C, Brügger B, Oturai AB, Dendrou CA, Fugger L.

A novel neurodegenerative spectrum disorder in patients with MLKL deficiency.

Cell Death Dis. 2020 May 1;11(5):303

Engel S, Graetz C, Salmen A, Muthuraman M, Toenges G, Ambrosius B, Bayas A, Berthele A, Heesen C, Klotz L, Kümpfel T, Linker RA, Meuth SG, Paul F, Stangel M, Tackenberg B, Then Bergh F, Tumani H, Weber F, Wildemann B, Zettl UK, Antony G, Bittner S, Groppa S, Hemmer B, Wiendl H, Gold R, Zipp F, Lill CM, Luessi F; German Competence Network of Multiple Sclerosis.

Is APOE ε4 associated with cognitive performance in early MS?

Neurol Neuroimmunol Neuroinflamm. 2020 May 1;7(4):e728.

Topp J, Heesen C, Augustin M, Andrees V,Blome C

Challenges and lessons learned from using anchoring vignettes to explore quality of liefe response behavior

Qual Life Res. 2020 Aug;29(8):2149-2159

Heitmann H, Haller B, Tiemann L, Mühlau M, Berthele A, Tölle TR, Salmen A, Ambrosius B, Bayas A, Asseyer S, Hartung HP, Heesen C, Stangel M, Wildemann B, Haars S, Groppa S, Luessi F, Kümpfel T, Nischwitz S, Meuth SG, Klotz L, Linker RA, Zettl UK, Ziemann U, Tumani H, Tackenberg B, Zipp F, Wiendl H, Gold R, Hemmer B, Ploner M.

Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study.

Pain. 2020 Apr;161(4):787-796

Dalgas U, Hvid LG, Kwakkel G, Motl RW, de Groot V, Feys P, Op't Eijnde B, Coote S, Beckerman H, Pfeifer K, Streber R, Peters S, Riemann-Lorenz K, Rosenkranz SC, Centonze D, Van Asch P, Bansi J, Sandroff BM, Pilutti LA, Ploughman M, Freeman J, Paul L, Dawes H, Romberg A, Kalron A, Stellmann JP, Friese MA, Heesen C.

Moving exercise research in multiple sclerosis forward (the MoXFo initiative): Developing consensus statements for research.

Mult Scler. 2020 Oct;26(11):1303-1308

Faizy TD, Thaler C, Broocks G, Flottmann F, Leischner H, Kniep H, Nawabi J, Schön G, Stellmann JP, Kemmling A, Reddy R, Heit JJ, Fiehler J, Kumar D, Hanning U.

The Myelin Water Fraction Serves as a Marker for Age-Related Myelin Alterations in the Cerebral White Matter – A Multiparametric MRI Aging Study.

Front Neurosci. 2020 Feb 24;14:136

Riemann-Lorenz K, Motl RW, Casey B, Coote S, Daubmann A, Heesen C.

Possible determinants of long-term adherence to physical activity in multiple sclerosis-theory-based development of a comprehensive questionnaire and results from a German survey study.

Disabil Rehabil. 2021 Nov;43(22):3175-3188

Aslan K, Turco V, Blobner J, Sonner JK, Liuzzi AR, Nunez NG, De Feo D, Kickingereder P, Fischer M, Green E, Sadik A, Friedrich M, Sanghvi K, Kilian M, Cichon F, Wolf L, Jähne K, von Landenberg A, Bunse L, Sahm F, Schriompf D., Meyer J, Allen A, Brugnara G, Röth R, Pfleiderer K, Niesler B, von Deimling A, Opitz C, Breckwoldt MO, Heiland S, Bendszus M, Wick W, Becher B, Platten M

Heterogeneity of Response to Immune Checkpoint Blockade in Hypermutated Expermimental Gliomas

Nat Commun 2020 Feb 178;11(1):931

Conversion to secondary progressive multiple sclerosis: Multistakeholder experiences and needs in Italy

PloS One 2020 Feb 13;15(2):e0228587

Has Silemek AC, Fischer L, Pöttgen J, Penner IK, Engel AK, Heesen C, Gold SM, Stellmann JP.

Functional and structural connectivity substrates of cognitive performance in relapsing remitting multiple sclerosis with mild disability.

Neuroimage Clin. 2020 Jan 12;25:102177

van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D; GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H.

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Acta Neuropathol 2020 May;139(5):959-962.

Stürner KH, Siembab I, Schön G, Stellmann JP, Heidari N, Fehse B, Heesen C, Eiermann TH, Martin R, Binder TM.

Is multiple sclerosis progression associated with the HLA-DR15 haplotype?

Mult Scler J Exp Transl Clin. 2019 Dec 9;5(4)

Ringelstein M, Harmel J, Zimmermann H, Brandt AU, Paul F, Haarmann A, Buttmann M, Hümmert MW, Trebst C, Schroeder C, Ayzenberg I, Kleiter I, Hellwig K, Havla J, Kümpfel T, Jarius S, Wildemann B, Rommer P, Weber MS, Pellkofer H, Röpke L, Geis C, Retzlaff N, Zettl U, Deppe M, Klotz L, Young K, Stellmann JP, Kaste M, Kermer P, Marouf W, Lauda F, Tumani H, Graf J, Klistorner A, Hartung HP, Aktas O, Albrecht P; Neuromyelitis Optica Study Group (NEMOS).

Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders.

Neurology. 2020 Jan 28;94(4):e407-e418

Gold SM, Otte C.

Differential impact of affective and cognitive symptoms on remission of major depression.

Lancet Psychiatry. 2019 Dec;6(12):980.

Topp J, Andrees V, Heesen C, Augustin M, Blome C

Recall of health-related quality of life: how does memory affect the SF-6D in patients with psoriasis or multiple sclerosis? A prospective observational study in Germany.

BMJ Open. 2019 Nov 21;9(11):e032859

Sonner, J. K., Keil, M., Falk-Paulsen, M., Mishra, N., Rehman, A., Kramer, M., Deumelandt, K., Röwe, J., Sanghvi, K., Wolf, L., von Landenberg, A., Wolff, H., Bharti, R., Oezen, I., Lanz, T. V., Wanke, F., Tang, Y., Brandao, I., Mohapatra, S. R., Epping, L., Grill, A., Röth, R., Niesler, B., Meuth, S. G., Opitz, C. A., Okun, J. G., Reinhardt, C., Kurschus, F. C., Wick, W., Bode, H. B., Rosenstiel, P., Platten, M.

Dietary Tryptophan Links Encephalogenicity of Autoreactive T Cells With Gut Microbial Ecology

Nat Commun 2019 Oct 25;10(1):4877

Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber N, Willing A, Rosenkranz SC, Diemert A, Harrison A, Vignali M, Sanders C, Robins HS, Tolosa E, Heesen C, Arck PC, Scheffold A, Chan K, Emerson RO, Friese MA, Gold SM.

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis.

Cell Rep. 2019 Oct 22;29(4):810-815

Palotai M, Nazeri A, Cavallari M, Healy BC, Glanz B, Gold SM, Weiner HL, Chitnis T, Guttmann CRG

History of fatigue in multiple sclerosis is associated with grey matter atrophy.

Sci Rep. 2019 Oct 14;9(1):14781.

Largey F, Jelcic I, Sospedra M, Heesen C, Martin R, Jelcic I.

Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS

Neurol Neuroimmunol Neuroinflamm. 2019 Sep 25;6(6)

Solari A, Giovannetti AM, Giordano A, Tortorella C, Torri Clerici V, Brichetto G, Granella F, Lugaresi A, Patti F, Salvetti M, Pesci I, Pucci E, Centonze D, Danni MC, Bonavita S, Ferraro D, Gallo A, Gajofatto A, Nociti V, Grimaldi L, Grobberio M, Lanzillo R, Di Giovanni R, Gregori S, Manni A, Pietrolongo E, Bertagnoli S, Ronzoni M, Compagnucci L, Fantozzi R, Allegri B, Arena S, Buscarinu MC, Sabattini L, Quartuccio ME, Tsantes E, Confaloneri P, Tacchino A, Schiffmann I, Rahn AC, Kleiter I, Messmer Uccelli M, Barabasch A, Heesen C, The ManTra Project

Conversion to Secondary Progressive Multiple Sclerosis: Patient Awareness and Needs. Results From an Online Survey in Italy and Germany.

Front Neurol. 2019 Aug 22;10:916.

Golde S., Wingenfeld K, Riepenhausen A, Schröter N, Fleischer J, Prüssner J, Grimm S, Fan Y, Hellmann-Regen J, Beck A, Gold SM, Otte C.

Healthy women with severe early life trauma show altered neural facilitation of emotion inhibition under acute stress.

Psychol Med. 2020; 50(12):2075-2084

Engler JB, Heckmann NF, Jäger J, Gold SM, Friese MA.

Pregnancy Enables Expansion of Disease-Specific Regulatory T Cells in an Animal Model of Multiple Sclerosis.

J Immunol. 2019 Oct 1;203(7):1743-1752.

Kesgin F, Suddick K, Heesen c, Wright J.

Developing a fall prevention program: what are the views and opinions of people with multiple sclerosis?

Dishabil. Rehabil. 2021 Apr;43(8):1065-1073

Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH.

Neuronal vulnerability and multilineage diversity in multiple sclerosis.

Nature. 2019 Sep;573(7772):75-82.

Bittner S, Engel S, Lange C, Weber MS, Haghikia A, Luessi F, Korn T, Klotz L, Bayas A, Paul F, Heesen C, Stangel M, Wildemann B, Bergh FT, Tackenberg B, Trebst C, Warnke C, Linker R, Kerschensteiner M, Zettl U, Tumani H, Brück W, Meuth SG1 Kümpfel T, Hemmer B, Wiendl H, Gold R, Zipp F.

Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommendations in Germany.

Nervenarzt. 2019 Dec;90(12):1245-1253

Andrees V, Westenhöfer J, Blome C, Heesen C, Augustin M, Topp J.

Towards patients‘ understanding of health-related quality of life-a mixed-method study in psoriasis and multiple sclerosis.

Qual Life Res. 2019 Oct;28(10):2717-2729.

Weygandt M, Behrens J, Brasanac J, Söder E, Meyer-Arndt L, Wakonig K, Ritter K, Brandt AU, Bellmann-Strobl J, Gold SM, Haynes JD, Paul F.

Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis.

Mult Scler Relat Disord. 2019 May 30;33:139-145

Alegiani AC, Albrecht S, Rahn AC, Köpke S, Thomalla G, Heesen C.

Reasons for delayed admission after stroke: results of a qualitative and quantitative survey.

Patient Prefer Adherence. 2019 May 8;13:739-747

van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W6,, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T5, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D; GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H.

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Acta Neuropathol. 2019 Aug;138(2):237-250

Faizy TD, Broocks G, Frischmuth I, Westermann C, Flottmann F, Schönfeld MH2, Nawabi J, Leischner H, Kutzner D2, Stellmann JP, Heesen C, Fiehler J, Gellißen S, Hanning U.

Spectrally fat-suppressed coronal 2D TSE sequences may be more sensitive than 2D STIR for the detection of hyperintense optic nerve lesions.

Eur Radiol. 2019 Nov;29(11):6266-6274

Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA.

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis.

Nat Neurosci. 2019 Jun;22(6):887-896

Pust GEA, Pöttgen J, Randerath J, Lau S, Heesen C, Gold SM, Penner IK

In search of distinct MS-related fatigue subtypes: results from a multi-cohort analysis in 1.403 MS patients.

J Neurol. 2019 Jul;266(7):1663-1673

Chae WR, Nagel JM, Kuehl LK, Gold SM, Wingenfeld K, Otte C.

Predictors of response and remission in a naturalistic inpatient sample undergoing multimodal treatment for depression.

J Affect Disord. 2019 Jun 1;252:99-106

Riemann-Lorenz K, Wienert J, Streber R, Motl RW, Coote S, Heesen C

Long-term physical activity in people with multiple sclerosis: exploring expert views on facilitators and barriers.

Disabil Rehabil. 2019 Mar 23:1-13

Schuster S, Ozga AK, Stellmann JP, Deb-Chatterji M, Häußler V, Matschke J, Gerloff C, Thomalla G, Magnus T.

Relapse rates and long-term outcome in primary angiitis of the central nervous system.

J Neurol. 2019 Jun;266(6):1481-1489

Schaefer LM, Poettgen J, Fischer A, Gold S, Stellmann JP, Heesen C

Impairment and restrictions in possibly benign multiple sclerosis.

Brain Behav. 2019 April;9(4):e01259

Faizy TD, Broocks G, Thaler C, Rauch G, Gebert P, Stürner KH, Flottmann F, Leischner H, Kniep HC, Stellmann JP, Heesen C, Fiehler J, Gellißen S, Hanning U

Development of Cortical Lesion Volumes on Double Inversion Recovery MRI in Patients With Relapse-Onset Multiple Sclerosis.

Front Neurol. 2019 Feb 22;10:133

Engels K, Schiffmann I, Weierstall R, Rahn AC, Daubmann A, Pust G, Chard D, Lukas C, Scheiderbauer J, Stellmann JP, Heesen C

Emotions towards magnetic resonance imaging in people with multiple sclerosis.

Acta Neurol Scand. 2019 Jun;139(6):497-504.

Tintelnot J, Ufer F, Engler JB, Winkler H, Lücke K, Mittrücker HW, Friese MA

Arc/Arg3.1 defines dendritic cells and Langerhans cells with superior migratory ability independent of phenotype and ontogeny in mice

Eur J Immunol. 2019 May;49(5):724-736

Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ.

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.

Immunity. 2019 Feb 19;50(2):462-476

Stork L, Brück W, von Gottberg P, Pulkowski U, Kirsten F, Glatzel M, Rauer S, Scheibe F, Radbruch H, Hammer E, Stürner KH, Kaulen B, Heesen C, Hoffmann F, Brock S, Pawlitzki M, Bopp T, Metz I.

Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis.

Mult Scler. 2019 Oct;25(12):1618-1632

Beckmann H, Augustin M, Heesen C, Poettgen J, Blome C.

Benefit evaluation in multiple sclerosis relapse treatment from the patients‘ perspective – Development and validation of a new questionnaire

Mult Scler Relat Disord. 2018 Dec 17;28:256-261

Hierweger AM, Engler JB, Friese MA, Reichardt HM, Lydon J, DeMayo F, Mittrücker HW, Arck PC.

Progesterone modulates the T cell response via glucocorticoid receptor-dependent pathways.

Am J Reprod Immunol. 2019 Feb.;81(2):e13084

Baquet L, Hasselmann H, Patra S, Stellmann JP, Vettorazzi E, Engel AK, Rosenkranz SC, Poettgen J, Gold SM, Schulz KH, Heesen C.

Short-term interval aerobic exercise training does not improve memory functioning in relapsing-remitting multiple sclerosis-a randomized controlled trial.

PeerJ. 2018 Dec 12;6:e6037

Heesen C., Rahn AC.

Guest Editorial: Shared Decision Making in Managing Multiple Sclerosis: Revisiting the Research Agenda.

Int J MS Care. 2018 Nov-Dec;20(6)

Hasselmann H, Gamradt S, Taenzer A, Nowacki J, Zain R, Patas K, Ramien C, Paul F, Wingenfeld K, Piber D, Gold SM, Otte C.

Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder.

Front Immunol. 2018 Nov 23;9:2693

Johnen A, Bürkner PC, Landmeyer NC, Ambrosius B, Calabrese P, Motte J, Hessler N, Antony G, König IR, Klotz L, Hoshi MM, Aly L, Groppa S, Luessi F, Paul F, Tackenberg B, Bergh FT, Kümpfel T, Tumani H, Stangel M, Weber F, Bayas A, Wildemann B, Heesen C, Zettl UK, Zipp F, Hemmer B, Meuth SG, Gold R, Wiendl H, Salmen A; German Competence Network Multiple Sclerosis (KKNMS).

Can we predict cognitive decline after initial diagnosis of multiple sclerosis? Results from the German National early MS cohort (KKNMS).

J Neurol. 2019 Feb;266(2):386-397

Giordano A, Liethmann K, Köpke S, Poettgen J, Rahn AC, Drulovic J, Beckmann Y, Sastre-Garriga J, Galea I, Heerings M, Jongen PJ, Vettorazzi E, Solari A, Heesen C; AutoMS group

Risk knowledge of people with relapsing-remitting multiple sclerosis – Results of an international survey

PLoS One. 2018 Nov 29;13(11):e0208004.

Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Krumbholz M, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl UK, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C; NEMOS (Neuromyelitis Optica Study Group).

Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions.

Neurol Neuroimmunol Neuroinflamm. 2018 Sep 26;5(6):e504

International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu; International Multiple Sclerosis Genetics Consortium. Mitrovič M, Patsopoulos NA, Beecham AH, Dankowski T, Goris A, Dubois B, D'hooghe MB, Lemmens R, Van Damme P, Søndergaard HB, Sellebjerg F, Sorensen PS, Ullum H, Thørner LW, Werge T, Saarela J, Cournu-Rebeix I, Damotte V, Fontaine B, Guillot-Noel L, Lathrop M, Vukusik S, Gourraud PA, Andlauer TFM, Pongratz V, Buck D, Gasperi C, Bayas A, Heesen C, Kümpfel T, Linker R, Paul F, Stangel M, Tackenberg B, Bergh FT, Warnke C, Wiendl H, Wildemann B, Zettl U, Ziemann U, Tumani H, Gold R, Grummel V, Hemmer B, Knier B, Lill CM, Luessi F, Dardiotis E, Agliardi C, Barizzone N, Mascia E, Bernardinelli L, Comi G, Cusi D, Esposito F, Ferrè L, Comi C, Galimberti D, Leone MA, Sorosina M, Mescheriakova J, Hintzen R, van Duijn C, Theunissen CE, Bos SD, Myhr KM, Celius EG, Lie BA, Spurkland A, Comabella M, Montalban X, Alfredsson L, Stridh P, Hillert J, Jagodic M, Piehl F, Jelčić I, Martin R, Sospedra M, Ban M, Hawkins C, Hysi P, Kalra S, Karpe F, Khadake J, Lachance G, Neville M, Santaniello A, Caillier SJ, Calabresi PA, Cree BAC, Cross A, Davis MF, Haines JL, de Bakker PIW, Delgado S, Dembele M, Edwards K, Fitzgerald KC, Hakonarson H, Konidari I, Lathi E, Manrique CP, Pericak-Vance MA, Piccio L, Schaefer C, McCabe C, Weiner H, Goldstein J, Olsson T, Hadjigeorgiou G, Taylor B, Tajouri L, Charlesworth J, Booth DR, Harbo HF, Ivinson AJ, Hauser SL, Compston A, Stewart G, Zipp F, Barcellos LF, Baranzini SE, Martinelli-Boneschi F, D'Alfonso S, Ziegler A, Oturai A, McCauley JL, Sawcer SJ, Oksenberg JR, De Jager PL, Kockum I, Hafler DA, Cotsapas C.

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk.

Cell. 2018 Nov 29;175(6):1679-1687

Heesen C, Scalfari A, Galea I.

Prognostic information for people with MS: Impossible or inevitable?

Mult Scler. 2020 Jun;26(7):771-773.

Tezer FI, Erdal A, Gumusyayla S, Has AC, Gocmen R, Oguz KK

Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy.

Sleep Med. 2018 Sep 18;52:128-133

Faizy TD, Kumar D, Broocks G, Thaler C, Flottmann F, Leischner H, Kutzner D, Hewera S, Dotzauer D, Stellmann JP,, Reddy R, Fiehler J, Sedlacik J, Gellißen S.

Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter.

Sci Rep. 2018 Oct 9;8(1):14991

Faizy TD, Kumar D, Broocks G, Thaler C, Flottmann F, Leischner H, Kutzner D, Hewera S, Dotzauer D, Stellmann JP, Reddy R, Fiehler J, Sedlacik J, Gellißen S.

Age-Related Measurements of the Myelin Water Fraction derived from 3D multi-echo GRASE reflect Myelin Content of the Cerebral White Matter.

Sci Rep. 2018 Oct 9;8(1):14991.

Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Walt I , Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.

Nat Microbiol. 2018 Oct;3(10):1161-1174.

Filser M, Schreiber H, Pöttgen J, Ullrich S, Lang M, Penner IK.

The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS): results from the German validation study.

J Neurol. 2018 Nov;265(11):2587-2593

Köpke S, Giordano A, Veronese S, Rahn AC, Kleiter I, Basedow-Rajwich B, Fornari A, Battaglia MA, Drulovic J, Kooij L, Koops J, Mens J, Meza Murillo ER, Milanov I, Milo R, Patti F, Pekmezovic T, Sastre-Garriga J, Vosburgh J, Voltz R, Bay J, Oliver DJ, Solari A.

Patient and caregiver involvement in the formulation of guideline questions: findings from the European Academy of Neurology guideline on palliative care of people with severe multiple sclerosis.

Eur J Neurol. 2019 Jan;26(1):41-50

Stoessel D, Stellmann JP, Willing A, Behrens B, Rosenkranz SC, Hodecker SC, Stürner KH, Reinhardt S, Fleischer S, Deuschle C, Maetzler W, Berg D, Heesen C, Walther D, Schauer N, Friese MA, Pless O

Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring.

Front Hum Neurosci. 2018 Jun 4;12:226

Buhse S, Rahn AC, Bock M, Mühlhauser I

Causal interpretation of correlational studies – Analysis of medical news on the website of the official journal for German physicians

Plos One. 2018 Max 3;13(5):e0196833

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, Leypoldt F; German Network for Research on Autoimmune Encephalitis (GENERATE).

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

Ann Neurol. 2018 Apr;83(4):863-869

Jarius S, Ruprecht K, Stellmann JP, Huss A, Ayzenberg I, Willing A, Trebst C, Pawlitzki M, Abdelhak A, Grüter T, Leypoldt F, Haas J, Kleiter I, Tumani H, Fechner K, Reindl M, Paul F, Wildemann B.

MOG-IgG in primary and secondary chronic progressive multiple sclerosis: a multicenter study of 200 patients and review of the literature.

J Neuroinflammation. 2018 Mar 19;15(1):88

Pöttgen J, Moss-Morris R, Wendebourg J, Feddersen L, Lau S, Köpke S, Meyer B, Friede T, Penner I, Heesen C, Gold SM

Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis

J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):970-976

Ridley B, Nagel AM, Bydder M, Maarouf A, Stellmann JP, Gherib S, Verneuil J, Viout P, Guye M, Ranjeva JP, Zaaraoui W.

Distribution of brain sodium long and short relaxation times and concentrations: a multi-echo ultra-high field 23Na MRI study.

Sci Rep. 2018 Mar 12;8(1):4357

Patas K, Willing A, Demiralay C, Engler JB, Lupu A, Ramien C, Schäfer T, Gach C, Stumm L, Chan K, Vignali M, Arck PC, Friese MA, Pless O, Wiedemann K, Agorastos A, Gold SM.

T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder.

Front Immunol. 2018 Feb 20;9:291

von Bismarck O, Dankowski T, Ambrosius B, Hessler N, Antony G, Ziegler A, Hoshi MM, Aly L, Luessi F, Groppa S, Klotz L, Meuth SG, Tackenberg B, Stoppe M, Then Bergh F, Tumani H, Kümpfel T, Stangel M, Heesen C, Wildemann B, Paul F, Bayas A, Warnke C, Weber F, Linker RA, Ziemann U, Zettl UK, Zipp F, Wiendl H, Hemmer B, Gold R, Salmen A.

Treatment choices and neuropsychological symptoms of a large cohort of early MS.

Neurol Neuroimmunol Neuroinflamm. 2018 Mar 1;5(3)

Pöttgen J, Rose A, van de Vis W4, Engelbrecht J5, Pirard M6, Lau S1,2, Heesen C1,2, Köpke S7; RiMS Special Interest Group Psychology and Neuropsychology.

Sexual dysfunctions in MS in relation to neuropsychiatric aspects and its psychological treatment: A scoping review.

PLoS One. 2018 Feb 27;13(2)

Willing A, Jäger J, Reinhardt S, Kursawe N, Friese MA.

Production of IL-17 by MAIT Cells Is Increased in Multiple Sclerosis and Is Associated with IL-7 Receptor Expression.

J Immunol. 2018 Feb 1;200(3):974-982

Stürner KH, Stellmann JP, Dörr J, Paul F, Friede T, Schammler S, Reinhardt S, Gellissen S, Weissflog G, Faizy TD, Werz O, Fleischer S, Vaas LAI, Herrmann F, Pless O, Martin R, Heesen C

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial).

J Neurol Neurosurg Psychiatry. 2018 Apr.;89(4):330-338

Heesen C, Haase R, Melzig S, Poettgen J, Berghoff M, Friedemann P, Zettl U, Marziniak M, Angstwurm K, Kern R, Ziemssen T, Stellmann JP

Perceptions on the value of bodily functions in multiple sclerosis.

Acta Neurol Scand. 2018 Mar;137(3):356-362

Gieras A, Gehbauer C, Perna-Barrull D, Engler JB, Diepenbruck I, Glau L, Joosse SA, Kersten N, Klinge S, Mittrücker HW, Friese MA, Vives-Pi M, Tolosa E

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity.

Front Immunol. 2017 Nov 13;8:1505

Thaler C, Faizy TD, Sedlacik J, Bester M, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

The use of multiparametric quantitative magnetic resonance imaging for evaluating visually assigned lesion groups in patients with multiple sclerosis.

J Neurol. 2018 Jan;265(1):127-133

Heesen C, Pöttgen J, Rahn AC, Liethmann K, Kasper J, Vahter L, Drulovic J, Van Nunen A, Wilkie D, Beckmann Y, Paul F, Köpke S, Giordano A, Solari A; AutoMS-group.

What should a person with relapsing-remitting multiple sclerosis know? – Focus group and survey data of a risk knowledge questionnaire (RIKNO 2.0).

Mult Scler Relat Disord. 2017 Nov;18:186-195

Akbulak RÖ, Rosenkranz SC, Schaeffer BN, Pinnschmidt HO, Willems S, Heesen C, Hoffmann BA

Acute and long-term effects of fingolimod on heart rhythm and heart rate variability in patients with multiple sclerosis.

Mult Scler Relat Disord. 2018 Jan;19:44-49

Schlüter K, Maier J, Patra S, Gold SM, Heesen C, Schulz KH1.

Aberrant peak lactate response in MS.

NeuroRehabilitation. 2017;41(4):811-822

Rosenkranz SC, Kaulen B, Neuhaus A, Siemonsen S, Köpke S, Daumer M, Stellmann JP, Heesen C

Low clinical conversion rate in clinically isolated syndrome (CIS) patients – diagnostic benefit of McDonald 2010 criteria?

Eur J Neurol. 2018 Feb;25(2):247-e9

Rahn AC, Köpke S, Backhus I, Kasper J, Anger K, Untiedt B, Alegiani A, Kleiter I, Mühlhauser I, Heesen C.

Nurse-led immunotreatment DEcision Coaching In people with Multiple Sclerosis (DECIMS) – Feasibility testing, pilot randomised controlled trial and mixed methods process evaluation.

Int J Nurs Stud. 2018 Feb.;78:26-36

Motl RW, Sandroff BM, Kwakkel G, Dalgas U, Feinstein A, Heesen C, Feys P, Thompson AJ

Exercise in patients with multiple sclerosis.

Lancet Neurol. 2017 Oct;16(10):848-856

Giovannetti AM, Giordano A, Pietrolongo E, Confalonieri P, De Luca G, Tortorella C, Trojano M, Messmer Uccelli M, Torri Clerici V, Gitto L, Köpke S, Borreani C, Heesen C, Solari A2 ManTra project.

Managing the transition (ManTra): a resource for persons with secondary progressive multiple sclerosis and their health professionals: protocol for a mixed-methods study in Italy.

BMJ Open. 2017 Aug 23;7(8):e017254

Stellmann JP, Hodecker S, Cheng B, Wanke N, Young KL, Hilgetag C, Gerloff C, Heesen C, Thomalla G, Siemonsen S.

Reduced rich-club connectivity is related to disability in primary progressive MS.

Neurol Neuroimmunol Neuroinflamm. 2017 Jul 27;4(5):e375

Thaler C, Schneider T, Sedlacik J, Kutzner D, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis.

PLoS One. 2017 Aug 10;12(8):e0183099.

Ufer F, Vargas P, Engler JB, Tintelnot J, Schattling B, Winkler H, Bauer S, Kursawe N, Willing A, Keminer O, Ohana O, Salinas-Riester G, Pless O, Kuhl D, Friese MA.

Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation

Sci. Immunol. 2016 Sep 23;1(3):eaaf86665

Gaissmaier W, Giese H, Galesic M, Garcia-Retamero R, Kasper J, Kleiter I, Meuth SG, Köpke S, Heesen C

Numeracy of multiple sclerosis patients: A comparison of patients from the PERCEPT study to a German probabilistic sample.

Patient Educ Couns. 2018 Jan;101(1):74-78

Kjolhede T, Siemonsen S, Wenzel D, Stellmann JP, Ringgaard S, Pedersen BG, Stenager E, Petersen T, Vissing K, Heesen C, Dalgas U

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Mult Scler. 2018 Sep;24(10):1356-1365

Weygandt M, Wakonig K, Behrens J, Meyer-Arndt L, Söder E, Brandt AU, Bellmann-Strobl J, Ruprecht K, Gold SM, Haynes JD, Paul F

Brain activity, regional gray matter loss, and decision-making in multiple sclerosis.

Mult Scler. 2018 Aug;24(9):1163-1173.

Reviews

Heesen C, Berger T, Riemann-Lorenz K, Krause N, Friede T, Pöttgen J, Meyer B, Lühmann D.

Mobile health interventions in multiple sclerosis: A systematic review.

Mult Scler 2023 Oct 28

Hadjilaou A, Brandi J, Riehn M, Friese MA, Jacobs T.

Pathogeneric mechanisms and treatment targets in cerebral malaria.

Nat Rev Neurol. 2023 Nov;19(11):688-709

Kümpfel T, Giglhuber K, Aktas O, Ayzenberg I, Bellmann-Strobl J, Häußler V, Havla J, Hellwig K, Hümmert MW, Jarius S, Kleiter I, Klotz L, Krumbholz M, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Trebst C, Tumani H, Warnke C, Wildemann B, Berthele A; Neuromyelitis Optica Study Group (NEMOS).

Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack Therapy and long-term management.

J Neurol. 2024 Jan;271(1):141-176

Jarius S, Aktas O, Ayzenberg I, Bellmann-Strobl J, Berthele A, Giglhuber K, Häußler V, Havla J, Hellwig K, Hümmert MW, Kleiter I, Klotz L, Krumbholz M, Kümpfel T, Paul F, Ringelstein M, Ruprecht K, Senel M, Stellmann JP, Bergh FT, Tumani H, Wildemann B, Trebst C; Neuromyelitis Optica Study Group (NEMOS).

Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis

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Treatment of autoimmunity: The impact of disease-modifying therapies in multiple sclerosis and comorbid autoimmune disorders.

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The Psychological Impact of Parental Multiple Sclerosis on Childred and Adolescents: A Systematic Review.

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Schubert C, Steinberg L, Peper J, Ramien C, Hellwig K, Köpke S, Solari A, Giordano A, Gold SM, Friede T, Heesen C, Rahn AC.

Postpartum relapse risk in multiple sclerosis: a systematic review and meta-anlysis.

Neurol Neurosurg Psychiatry. 2023 Sep;94(9):718-725.

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Driving ability and predictors for driving performance in Multiple Sclerosis: A systematic review.

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