Our immunological studies focus on what provokes autoimmunity. We aim to decipher the deregulated cell types in multiple sclerosis and other neuroimmunological diseases and here in particular T cells and dendritic cells. We want to understand the molecules that serve as regulators of immune cell function and the effector molecules that invigorate an autoimmune response. In addition, learning from evolution, e.g. by understanding how pregnancy and sex differences shape immune responses, will help the quest for novel immunomodulatory treatments for neuroimmunological diseases.