Extracellular adenosine triphosphate (ATP) and diphosphate (ADP) act as key signalling molecules in the central nervous system (CNS) and regulate neuroinflammatory responses through purinergic receptors. Although astrocytes and neurons undergo profound changes in signalling and metabolism during inflammation, the contribution of specific purinergic pathways to inflammation-induced neurodegeneration remains unclear. Here we show that the ADP/ATP-activated… Read more »
Archiv nach Monat:: Juni 2026
Motherhood Choice in multiple sclerosis (MoMS) – Pilot trial of web-based decision support.
Backgroud: Uncertainty concerning motherhood is common among women with multiple sclerosis (wwMS). Therefore, we developed and pre-tested a patient decision aid (PtDA) and a nurse-led decision coaching intervention (DC) to support motherhood choice. The DC includes the PtDA, a decision guide on motherhood choice, and decision coaching. Methods: We conducted a randomised pilot trial across… Read more »
Immunotherapy decision coaching for people with multiple sclerosis- Implementation of an interprofessional decision support programme into clinical practice.
Background: Aiming at actively involving patients in the complex immunotherapy decision-making process in multiple sclerosis (MS), we developed DECIMS (Decision Coaching in people with Multiple Sclerosis). This interprofessional decision-support programme consists of nurse-led coaching sessions, an online accessible information tool (DECIMS-Wiki), and a physician’s consultation. Objective: To assess the implementation of nurse-led decision coaching in… Read more »
The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis
Aerobic exercise is a disease-modifying intervention in multiple sclerosis (MS) that ameliorates several progressive neurological symptoms in people with MS. Here we show that the exercise hormone irisin mediates neuroprotective effects of exercise in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. We demonstrate that voluntary free-wheel running exercise protects against inflammation-induced neurodegeneration in… Read more »
Sex-specific analysis of early disease course and treatment in a German multiple sclerosis cohort.
Background: Understanding sex differences in relapsing-remitting multiple sclerosis (RRMS) and initiation of disease-modifying treatments (DMTs) is crucial for tailored approaches. Objective: The objective of this study is to analyze sex-specific differences in early RRMS. Methods: We analyzed data of therapy-naïve adults from the German NationMS cohort to describe first symptoms, onset relapse treatment, disability evolution,… Read more »
Multicentric prognostic observational study on biomarker profile in immunotherapy-naïve patients with highly active generalized myasthenia gravis (PROGNO-MG): a study protocol
Background: Myasthenia gravis has a variable disease course. Early identification of patients with a highly active disease is crucial to prevent myasthenic exacerbations and crisis, necessitating more aggressive immunotherapy. However, no biomarkers currently exist to identify patients at risk for highly active disease course. Objective: The PROGNO-MG study aims to identify blood-based biomarker signatures associated… Read more »
Neueste Kommentare