Archiv nach Monat:: Januar 2026

A GDF-15-GFRAL axis controls autoimmune T cell responses during neuroinflammation

Veröffentlicht: von & gespeichert unter Allgemein.

Inflammatory activity during multiple sclerosis (MS) often improves during pregnancy, suggesting that pregnancy-related immune adaptations affect the disease. Here we show that growth/differentiation factor-15 (GDF-15) increases during pregnancy and correlates with a reduced rate of MS relapses. GDF-15 also accumulates in the inflamed central nervous system, and its absence impairs inflammation resolution in a mouse… Read more »