Archiv nach Monat:: August 2025

Background: This randomised controlled trial investigated the effect of a personalised digital lifestyle management application (‚levidex‘) on inflammatory disease activity in newly diagnosed people with MS (pwMS), compared to a non-personalised application (‚dexilev‘) that covered similar lifestyle-related content. Methods: Participants (N = 234) were recruited from July 2019 to April 2022 in 20 study centres… Read more »

Background: Anxiety is a common yet often underdiagnosed and undertreated comorbidity in multiple sclerosis (MS). While altered fear processing is a hallmark of anxiety in other populations, its neurobehavioral mechanisms in MS remain poorly understood. This study investigates the extent to which neurobehavioral mechanisms of fear generalization contribute to anxiety in MS. Methods: We recruited… Read more »

Objectives: Heated tobacco products (HTPs) are electronic devices that heat tobacco instead of burning it to produce an inhalable aerosol. This study aimed to investigate usage patterns, sociodemographic and socioeconomic factors, as well as co-use characteristics of people who use HTPs within the German population to inform interventions and preventive measures. Methods: We conducted analysis… Read more »

„Background: Glatiramer acetate (GA) is a well-tolerated treatment for multiple sclerosis (MS) and comparable in its efficacy to high-dose interferon beta (IFN). As a lack of validated treatment response biomarkers for MS hampers progress in personalised treatment, the study goal was to search for biomarkers of a successful treatment response utilising the known observation of… Read more »

Introduction: Since multiple sclerosis (MS) primarily affects women of childbearing age, the disease intersects with a critical period for family planning and pregnancy. This is important, since pregnancy itself can influence psychological well-being, contributing to symptoms such as depression, stress and fatigue. However, while mental health during late pregnancy and the postpartum period has been… Read more »